About the Authors

Jesse M. Damsker

Jesse.Damsker@reveragen.com

Affiliation ReveraGen BioPharma, Rockville, Maryland, United States of America

Blythe C. Dillingham

Affiliations ReveraGen BioPharma, Rockville, Maryland, United States of America, Research Center for Genetic Medicine, Children's National Medical Center, Washington DC, United States of America

Mary C. Rose

Affiliations Research Center for Genetic Medicine, Children's National Medical Center, Washington DC, United States of America, Department of Integrative Systems Biology, Children's National Medical Center and George Washington University School of Medicine and Health Sciences, Washington DC, United States of America

Molly A. Balsley

Affiliation Department of Microbiology, Immunology, and Tropical Medicine, the George Washington University Medical Center, Washington DC, United States of America

Christopher R. Heier

Affiliation Research Center for Genetic Medicine, Children's National Medical Center, Washington DC, United States of America

Alan M. Watson

Affiliation Research Center for Genetic Medicine, Children's National Medical Center, Washington DC, United States of America

Erik J. Stemmy

Affiliation Department of Microbiology, Immunology, and Tropical Medicine, the George Washington University Medical Center, Washington DC, United States of America

Roslyn A. Jurjus

Affiliation Department of Microbiology, Immunology, and Tropical Medicine, the George Washington University Medical Center, Washington DC, United States of America

Tony Huynh

Affiliations Research Center for Genetic Medicine, Children's National Medical Center, Washington DC, United States of America, Endocrine Research Unit and the Australian National University Medical School, The Canberra Hospital, Australian Capital Territory, Australia

Kathleen Tatem

Affiliation Research Center for Genetic Medicine, Children's National Medical Center, Washington DC, United States of America

Kitipong Uaesoontrachoon

Affiliation Research Center for Genetic Medicine, Children's National Medical Center, Washington DC, United States of America

Dana M. Berry

Affiliation Research Center for Genetic Medicine, Children's National Medical Center, Washington DC, United States of America

Angela S. Benton

Affiliation Research Center for Genetic Medicine, Children's National Medical Center, Washington DC, United States of America

Robert J. Freishtat

Affiliations Research Center for Genetic Medicine, Children's National Medical Center, Washington DC, United States of America, Department of Integrative Systems Biology, Children's National Medical Center and George Washington University School of Medicine and Health Sciences, Washington DC, United States of America

Eric P. Hoffman

Affiliations ReveraGen BioPharma, Rockville, Maryland, United States of America, Research Center for Genetic Medicine, Children's National Medical Center, Washington DC, United States of America, Department of Integrative Systems Biology, Children's National Medical Center and George Washington University School of Medicine and Health Sciences, Washington DC, United States of America

John M. McCall

Affiliations ReveraGen BioPharma, Rockville, Maryland, United States of America, PharMac LLC, Boca Grande, Florida, United States of America

Heather Gordish-Dressman

Affiliations Research Center for Genetic Medicine, Children's National Medical Center, Washington DC, United States of America, Department of Integrative Systems Biology, Children's National Medical Center and George Washington University School of Medicine and Health Sciences, Washington DC, United States of America

Stephanie L. Constant

Affiliation Department of Microbiology, Immunology, and Tropical Medicine, the George Washington University Medical Center, Washington DC, United States of America

Erica K. M. Reeves

Affiliation ReveraGen BioPharma, Rockville, Maryland, United States of America

Kanneboyina Nagaraju

Affiliations ReveraGen BioPharma, Rockville, Maryland, United States of America, Research Center for Genetic Medicine, Children's National Medical Center, Washington DC, United States of America, Department of Integrative Systems Biology, Children's National Medical Center and George Washington University School of Medicine and Health Sciences, Washington DC, United States of America

Competing Interests

Jesse M. Damsker is an employee of ReveraGen BioPharma and has stock options. Blythe C. Dillingham was an employee of ReveraGen BioPharma during the time the work was done on this manuscript. Erica K. M. Reeves is an employee of ReveraGen BioPharma and has stock options. John M. McCall is an employee of PharMac LLC and has founder shares and a board membership with ReveraGen BioPharma. Eric P. Hoffman has founder shares and a board membership with ReveraGen BioPharma. Finally, Kanneboyina Nagaraju has founder shares and a board membership with ReveraGen BioPharma. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: JMD SLC RJF KN. Performed the experiments: JMD BCD MAB CRH AMW EJS RAJ TH KT KU DMB ASB. Analyzed the data: JMD BCD SLC HGD KN. Contributed reagents/materials/analysis tools: EKMR RJF SLC KN. Wrote the paper: JMD MCR.