A Kir6.2 Pore Mutation Causes Inactivation of ATP-Sensitive Potassium Channels by Disrupting PIP2-Dependent Gating

Jeremy D. Bushman; Qing Zhou; Show-Ling Shyng

doi:10.1371/journal.pone.0063733

Loading metrics

Open Access

Peer-reviewed

Research Article

A Kir6.2 Pore Mutation Causes Inactivation of ATP-Sensitive Potassium Channels by Disrupting PIP₂-Dependent Gating

Jeremy D. Bushman,

Current address: Department of Biological Sciences, University of Southern California, Los Angeles, California, United States of America

Affiliation Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, Oregon, United States of America
⨯
Qing Zhou,

Affiliation Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, Oregon, United States of America
⨯
Show-Ling Shyng

* E-mail: shyngs@ohsu.edu

Affiliation Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, Oregon, United States of America
⨯

A Kir6.2 Pore Mutation Causes Inactivation of ATP-Sensitive Potassium Channels by Disrupting PIP₂-Dependent Gating

Jeremy D. Bushman,
Qing Zhou,
Show-Ling Shyng

Published: May 20, 2013
https://doi.org/10.1371/journal.pone.0063733

About the Authors

Jeremy D. Bushman

Current address: Department of Biological Sciences, University of Southern California, Los Angeles, California, United States of America

Affiliation Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, Oregon, United States of America

Qing Zhou

Affiliation Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, Oregon, United States of America

Show-Ling Shyng

* E-mail: shyngs@ohsu.edu

Affiliation Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, Oregon, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JDB SLS. Performed the experiments: JDB QZ SLS. Analyzed the data: JDB QZ SLS. Contributed reagents/materials/analysis tools: JDB SLS. Wrote the paper: JDB SLS.

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Ion channel gating
Is the Subject Area "Ion channel gating" applicable to this article?

Thanks for your feedback.
Neomycins
Is the Subject Area "Neomycins" applicable to this article?

Thanks for your feedback.
Glycine
Is the Subject Area "Glycine" applicable to this article?

Thanks for your feedback.
Potassium channels
Is the Subject Area "Potassium channels" applicable to this article?

Thanks for your feedback.
Membrane potential
Is the Subject Area "Membrane potential" applicable to this article?

Thanks for your feedback.
Proline
Is the Subject Area "Proline" applicable to this article?

Thanks for your feedback.
Chemiluminescence
Is the Subject Area "Chemiluminescence" applicable to this article?

Thanks for your feedback.
Substitution mutation
Is the Subject Area "Substitution mutation" applicable to this article?

Thanks for your feedback.