About the Authors

Hongmei Zhao

Contributed equally to this work with: Hongmei Zhao, Jozsef Karman

Affiliation Genzyme, a Sanofi Company, Framingham, Massachusetts, United States of America

Jozsef Karman

Contributed equally to this work with: Hongmei Zhao, Jozsef Karman

Affiliation Genzyme, a Sanofi Company, Framingham, Massachusetts, United States of America

Ji-Lei Jiang

Affiliation Genzyme, a Sanofi Company, Framingham, Massachusetts, United States of America

Jinhua Zhang

Current address: Livzon Mabpharm, Inc., Guangdong, P. R. China

Affiliation Genzyme, a Sanofi Company, Framingham, Massachusetts, United States of America

Nathan Gumlaw

Affiliation Genzyme, a Sanofi Company, Framingham, Massachusetts, United States of America

John Lydon

Affiliation Genzyme, a Sanofi Company, Framingham, Massachusetts, United States of America

Qun Zhou

Affiliation Genzyme, a Sanofi Company, Framingham, Massachusetts, United States of America

Huawei Qiu

Affiliation Genzyme, a Sanofi Company, Framingham, Massachusetts, United States of America

Canwen Jiang

Current address: Alcon Research, Ltd., Fort Worth, Texas, United States of America

Affiliation Genzyme, a Sanofi Company, Framingham, Massachusetts, United States of America

Seng H. Cheng

Affiliation Genzyme, a Sanofi Company, Framingham, Massachusetts, United States of America

Yunxiang Zhu

yunxiang.zhu@genzyme.com

Affiliation Genzyme, a Sanofi Company, Framingham, Massachusetts, United States of America

Competing Interests

All authors were employees of Genzyme, a Sanofi Company when the work was performed. Some of the employees are also shareholders of the company. This work is also part of a patent application titled “INHIBITORS OF T-CELL ACTIVATION” (International Application No: PCT/US2012/045017). CJ is now an employee of Alcon Research. Ltd., and JZ is an employee of Livzon Mabpharm. However, this does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: YXZ HMZ JK HWQ QZ CWJ SHC. Performed the experiments: HMZ JK JLJ JHZ NG JL QZ HWQ. Analyzed the data: YXZ JK HMZ QZ HWQ. Wrote the paper: YXZ JK SHC.