About the Authors

Tomoyuki Igawa

igawatmy@chugai-pharm.co.jp

Affiliation Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan

Atsuhiko Maeda

Affiliation Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan

Kenta Haraya

Affiliation Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan

Tatsuhiko Tachibana

Affiliation Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan

Yuki Iwayanagi

Affiliation Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan

Futa Mimoto

Affiliation Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan

Yoshinobu Higuchi

Affiliation Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan

Shinya Ishii

Affiliation Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan

Shigero Tamba

Affiliation Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan

Naoka Hironiwa

Affiliation Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan

Kozue Nagano

Affiliation Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan

Tetsuya Wakabayashi

Affiliation Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan

Hiroyuki Tsunoda

Affiliation Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan

Kunihiro Hattori

Affiliation Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan

Competing Interests

All authors are employees of Chugai Pharmaceutical Co., Ltd. T.I. and A.M. are inventors of the patents which claim pH-dependent binding antibody and sweeping antibody. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Provided direction and guidance: HT K. Hattori. Conceived and designed the experiments: TI. Performed the experiments: AM K. Haraya TT YI KN YH SI. Analyzed the data: K. Haraya TT YI FM. Contributed reagents/materials/analysis tools: NH ST TW. Wrote the paper: TI.