About the Authors

Vincent Wai-Sun Wong

Contributed equally to this work with: Vincent Wai-Sun Wong, Chi-Hang Tse, Tommy Tsan-Yuk Lam

wongv@cuhk.edu.hk

Affiliations Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong

Chi-Hang Tse

Contributed equally to this work with: Vincent Wai-Sun Wong, Chi-Hang Tse, Tommy Tsan-Yuk Lam

Affiliations Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong

Tommy Tsan-Yuk Lam

Contributed equally to this work with: Vincent Wai-Sun Wong, Chi-Hang Tse, Tommy Tsan-Yuk Lam

Affiliation Department of Zoology, University of Oxford, Oxford, United Kingdom

Grace Lai-Hung Wong

Affiliations Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong

Angel Mei-Ling Chim

Affiliations Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong

Winnie Chiu-Wing Chu

Affiliation Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong

David Ka-Wai Yeung

Affiliation Department of Clinical Oncology, The Chinese University of Hong Kong, Hong Kong

Patrick Tik-Wan Law

Affiliation School of Life Sciences, The Chinese University of Hong Kong, Hong Kong

Hoi-Shan Kwan

Affiliation School of Life Sciences, The Chinese University of Hong Kong, Hong Kong

Jun Yu

Affiliations Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong

Joseph Jao-Yiu Sung

Affiliations Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong

Henry Lik-Yuen Chan

Affiliations Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong

Competing Interests

Vincent Wai-Sun Wong has been an advisory board member of Roche, Novartis, Gilead and Otsuka, and received paid lecture fees from Roche, Novartis, Abbott Diagnostics and Echosens. Grace Lai-Hung Wong has been an advisory board member of Otsuka, and received paid lecture fees from Echosens and Otsuka. Henry Lik-Yuen Chan has been consultant for Abbott, Bristol-Myers Squibb, Merck, Novartis and Roche, and received paid lecture fees from Abbott, Bristol-Myers Squibb, Echosens, Gilead, Glaxo-Smith-Kline, Merck, Novartis and Roche.This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: VW HC. Performed the experiments: VW CT TL. Analyzed the data: VW CT TL. Contributed reagents/materials/analysis tools: GW AC WC DY PL HK JY JS HC. Wrote the paper: VW CT TL. Radiological analysis: WC DY CT TL PL HK JY JS HC.