About the Authors

Georgina Arrambide

Contributed equally to this work with: Georgina Arrambide, Carmen Espejo

Affiliation Department of Neurology-Neuroimmunology, Multiple Sclerosis Centre of Catalonia (Cemcat), Vall d’Hebron University Hospital and Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain

Carmen Espejo

Contributed equally to this work with: Georgina Arrambide, Carmen Espejo

Affiliation Department of Neurology-Neuroimmunology, Multiple Sclerosis Centre of Catalonia (Cemcat), Vall d’Hebron University Hospital and Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain

Jennifer Yarden

Affiliation Department of Research and Development, Glycominds, Modi’in, Israel

Ella Fire

Affiliation Department of Research and Development, Glycominds, Modi’in, Israel

Larissa Spector

Affiliation Department of Research and Development, Glycominds, Modi’in, Israel

Nir Dotan

Affiliation Department of Research and Development, Glycominds, Modi’in, Israel

Avinoam Dukler

Affiliation Department of Research and Development, Glycominds, Simi Valley, California, United States of America

Alex Rovira

Affiliation Magnetic Resonance Unit (IDI), Vall d’Hebron University Hospital, Barcelona, Spain

Xavier Montalban

Affiliation Department of Neurology-Neuroimmunology, Multiple Sclerosis Centre of Catalonia (Cemcat), Vall d’Hebron University Hospital and Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain

Mar Tintore

mtintore@vhebron.net

Affiliation Department of Neurology-Neuroimmunology, Multiple Sclerosis Centre of Catalonia (Cemcat), Vall d’Hebron University Hospital and Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain

Competing Interests

Georgina Arrambide has received travel expenses for the 2011 CMSC (Consortium of Multiple Sclerosis Centers) meeting from Glycominds. Carmen Espejo has received speaking honoraria from Merck Serono and Almirall. Jennifer Yarden, Ella Fire, Larissa Spector, and Nir Dotan are employees and stock holders of Glycominds. Avinoam Dukler is an employee and share and stock holder of Glycominds. Alex Rovira serves on scientific advisory boards for NeuroTEC and on the editorial board of the American Journal of Neuroradiology and Neuroradiology, has received speaker honoraria from Bayer Schering Pharma, Sanofi-Aventis, Bracco, Merck Serono, Teva Pharmaceutical Industries Ltd. and Biogen Idec, receives research support from Bayer Schering Pharma, and serves as a consultant for Novartis. Xavier Montalban has received speaking honoraria and travel expenses for scientific meetings, has been a steering committee member of clinical trials or participated in advisory boards of clinical trials in the past with Bayer Schering Pharma, Biogen Idec, EMD Merck Serono, Genentech, Genzyme, Novartis, Sanofi-Aventis, Teva Pharmaceuticals and Almirall. Mar Tintoré has received compensation for consulting services and speaking honoraria from Bayer-Schering, Merck-Serono, Biogen-Idec, Teva, Sanofi-Aventis, and Novartis. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Contributed in analyzing the MRI data: AR. Conceived and designed the experiments: GA CE JY ND XM MT. Performed the experiments: EF LS. Analyzed the data: GA CE JY ND AD AR XM MT. Contributed reagents/materials/analysis tools: GA CE JY EF LS ND AD XM MT. Wrote the paper: GA CE JY AR XM MT.