About the Authors

Michael Brunsteiner

Affiliations Research Center Pharmaceutical Engineering, Graz, Austria, Institute of Biotechnology and Biochemical Engineering, Graz University of Technology, Graz, Austria

Michaela Flock

Affiliation Institute of Inorganic Chemistry, Graz University of Technology, Graz, Austria

Bernd Nidetzky

bernd.nidetzky@tugraz.at

Affiliation Institute of Biotechnology and Biochemical Engineering, Graz University of Technology, Graz, Austria

Competing Interests

This study was partially funded by Sandoz GmbH (Kundl, Austria, pharmaceutical company, www.sandoz.at). This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: MB. Performed the experiments: MB. Analyzed the data: MB MF BN. Wrote the paper: MB BN.