About the Authors

Wei Wu

Affiliation Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia

Joseph A. Nicolazzo

Affiliation Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Victoria, Australia

Li Wen

Affiliation Cornea and NSW Eye Bank, The University of Sydney, Sydney, New South Wales, Australia

Roger Chung

Affiliation Menzies Research Institute Tasmania, The University of Tasmania, Hobart, Tasmania, Australia

Roger Stankovic

Affiliation Discipline of Pathology, The University of Sydney, Sydney, New South Wales, Australia

Shisan S. Bao

Affiliation Discipline of Pathology, The University of Sydney, Sydney, New South Wales, Australia

Chai K. Lim

Affiliations Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia, MND and Neurodegenerative Disease Research Group, Macquarie University, North Ryde, New South Wales, Australia

Bruce J. Brew

Affiliations St Vincent's Centre for Applied Medical Research, Darlinghurst, New South Wales, Australia, Departments of Neurology and HIV Medicine, St. Vincent's Hospital, Darlinghurst, New South Wales, Australia

Karen M. Cullen

Contributed equally to this work with: Karen M. Cullen, Gilles J. Guillemin

Affiliation Discipline of Anatomy and Histology, The University of Sydney, Sydney, New South Wales, Australia

Gilles J. Guillemin

Contributed equally to this work with: Karen M. Cullen, Gilles J. Guillemin

gilles.guillemin@mq.edu.au

Affiliations Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia, MND and Neurodegenerative Disease Research Group, Macquarie University, North Ryde, New South Wales, Australia

Competing Interests

The authors have the following interest. Prof. Gilles Guillemin is a PLOS ONE Editorial Board member. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: WW JAN KMC GJG. Performed the experiments: WW JAN LW CKL RC RS SSB KMC. Analyzed the data: WW JAN RS BJB CKL KMC GJG. Contributed reagents/materials/analysis tools: JAN RS RC CKL KMC BJB GJG. Wrote the paper: WW JAN KMC CKL GJG.