About the Authors

Xianda Zhao

Contributed equally to this work with: Xianda Zhao, Yuyu He

Affiliation Department of Pathology, School of Basic Medical Science, Wuhan University, Wuhan, P. R. China

Yuyu He

Contributed equally to this work with: Xianda Zhao, Yuyu He

Affiliation Department of Pathology, School of Basic Medical Science, Wuhan University, Wuhan, P. R. China

Jun Gao

Affiliation Department of Molecular Pathology, Wuhan Nano Tumor Diagnosis Engineering Research Center, Wuhan, P. R. China

Lifang Fan

Affiliation Department of Pathology, School of Basic Medical Science, Wuhan University, Wuhan, P. R. China

Zonghuan Li

Affiliation Department of Pathology, School of Basic Medical Science, Wuhan University, Wuhan, P. R. China

Guifang Yang

Affiliation Department of Pathology, Zhongnan Hospital of Wuhan University, Wuhan, P. R. China

Honglei Chen

hl-chen@whu.edu.cn

Affiliations Department of Pathology, School of Basic Medical Science, Wuhan University, Wuhan, P. R. China, Department of Biochemistry, Rush University Medical Center, Chicago, Illinois, United States of America

Competing Interests

Guilin Fanpu Biotechnology Co., Ltd gave technological support for TMA construction. There are no patents, products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: XZ YH JG HC. Performed the experiments: XZ YH JG LF ZL GY HC. Analyzed the data: XZ YH JG ZL HC. Contributed reagents/materials/analysis tools: XZ YH JG ZL HC. Wrote the paper: XZ YH JG HC.