About the Authors

Yu-Jue Wang

Contributed equally to this work with: Yu-Jue Wang, Wen Liu, Chi Chen, Li-Meng Yan

Affiliations Department of Laboratory Animal Center, Southern Medical University, Guangzhou, Guangdong, China, Pearl Laboratory Animal Sci. & Tech. Co. Ltd., Dongguan, China

Wen Liu

Contributed equally to this work with: Yu-Jue Wang, Wen Liu, Chi Chen, Li-Meng Yan

Affiliation Department of Laboratory Animal Center, Southern Medical University, Guangzhou, Guangdong, China

Chi Chen

Contributed equally to this work with: Yu-Jue Wang, Wen Liu, Chi Chen, Li-Meng Yan

Affiliation Department of Hematology, The People’s Hospital of Guizhou Province, Guiyang, Guizhou, China

Li-Meng Yan

Contributed equally to this work with: Yu-Jue Wang, Wen Liu, Chi Chen, Li-Meng Yan

Affiliation Department of Ophthalmology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China

Jun Song

Affiliation Department of Hematology, The People’s Hospital of Guizhou Province, Guiyang, Guizhou, China

Kun-Yuan Guo

doctorguokunyuan@yahoo.com.cn (KYG); doctorguweiwang@yahoo.com.cn (WWG)

Affiliation Department of Hematology, Zhujiang Hospital, The Southern Medical University, Guangzhou, Guangdong, China

Gang Wang

Affiliation Department of Oncology, Affiliated Oncology Hospital of Medical College of Guiyang, Guiyang, Guizhou, China

Qing-Hong Wu

Affiliation Department of Laboratory Animal Center, Southern Medical University, Guangzhou, Guangdong, China

Wei-Wang Gu

doctorguokunyuan@yahoo.com.cn (KYG); doctorguweiwang@yahoo.com.cn (WWG)

Affiliation Department of Laboratory Animal Center, Southern Medical University, Guangzhou, Guangdong, China

Competing Interests

Yujue Wang and Weiwang Gu are animal care consultants of Pearl Laboratory Animal Sci&tech Co. Ltd., this company provides minipigs for this study. This does not alter the authors' adherence to all PLOS ONE policies on sharing data and materials.

Author Contributions

Organized the team work: YJW GW. Took care of the animals: WL QHW. Conceived and designed the experiments: YJW WL KYG YJW CC GW WWG. Performed the experiments: LMY GW WL JS. Analyzed the data: QHW CC. Contributed reagents/materials/analysis tools: CC YJW GW. Wrote the paper: CC YJW WWG.