About the Authors

Ying-Lien Chen

Affiliations Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America, Department of Plant Pathology and Microbiology, National Taiwan University, Taipei, Taiwan

Virginia N. Lehman

Affiliations Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America, Department of Biomedical Engineering, Duke University, Durham, North Carolina, United States of America

Anna F. Averette

Affiliation Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America

John R. Perfect

Affiliation Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America

Joseph Heitman

heitm001@duke.edu

Affiliation Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America

Competing Interests

The authors have declared that no competing interests exist. Because the authors have received funding from a commercial source (Merck & Co., Inc. and Astellas Pharma, Inc.), they would like to declare the following statement: this does not alter their adherence to all of the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: YC JP JH. Performed the experiments: YC VL AA. Analyzed the data: YC VL JH. Wrote the paper: YC VL JP JH.