Cytokeratin19-2g2, a Novel Fragment of Cytokeratin19 in Serum, Indicating a More Invasive Behavior and Worse Prognosis in Breast Cancer Patients

Yanan Kong; Junye Wang; Wanli Liu; Qiaolun Chen; Juan Yang; Weidong Wei; Mingqing Wu; Lu Yang; Xinhua Xie; Ning Lv; Jiaoli Guo; Laisheng Li; Jie Gao; Xiaoming Xie; Shuqin Dai

doi:10.1371/journal.pone.0057092

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Open Access

Peer-reviewed

Research Article

Cytokeratin19-2g2, a Novel Fragment of Cytokeratin19 in Serum, Indicating a More Invasive Behavior and Worse Prognosis in Breast Cancer Patients

Yanan Kong ,

Contributed equally to this work with: Yanan Kong, Junye Wang

Affiliations Department of Breast Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, People’s Republic of China, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, People’s Republic of China
⨯
Junye Wang ,

Contributed equally to this work with: Yanan Kong, Junye Wang

Affiliations State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, People’s Republic of China, Department of Chest Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, People’s Republic of China
⨯
Wanli Liu,

Affiliations State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, People’s Republic of China, Department of Medical Examination, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, People’s Republic of China
⨯
Qiaolun Chen,

Affiliations State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, People’s Republic of China, Department of Medical Examination, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, People’s Republic of China
⨯
Juan Yang,

Affiliations State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, People’s Republic of China, Department of Medical Examination, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, People’s Republic of China
⨯
Weidong Wei,

Affiliations Department of Breast Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, People’s Republic of China, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, People’s Republic of China
⨯
Mingqing Wu,

Affiliations Department of Breast Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, People’s Republic of China, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, People’s Republic of China
⨯
Lu Yang,

Affiliations Department of Breast Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, People’s Republic of China, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, People’s Republic of China
⨯
Xinhua Xie,

Affiliations Department of Breast Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, People’s Republic of China, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, People’s Republic of China
⨯
Ning Lv,

Affiliations Department of Breast Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, People’s Republic of China, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, People’s Republic of China
⨯
Jiaoli Guo,

Affiliations Department of Breast Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, People’s Republic of China, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, People’s Republic of China
⨯
Laisheng Li,

Affiliations Department of Breast Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, People’s Republic of China, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, People’s Republic of China
⨯
Jie Gao,

Affiliations Department of Breast Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, People’s Republic of China, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, People’s Republic of China
⨯
Xiaoming Xie ,

* E-mail: daishq@sysucc.org.cn (SD); xiexm@sysucc.org.cn (XX)

Affiliations Department of Breast Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, People’s Republic of China, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, People’s Republic of China
⨯
Shuqin Dai

* E-mail: daishq@sysucc.org.cn (SD); xiexm@sysucc.org.cn (XX)

Affiliations State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, People’s Republic of China, Department of Medical Examination, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, People’s Republic of China
⨯

Cytokeratin19-2g2, a Novel Fragment of Cytokeratin19 in Serum, Indicating a More Invasive Behavior and Worse Prognosis in Breast Cancer Patients

Yanan Kong,
Junye Wang,
Wanli Liu,
Qiaolun Chen,
Juan Yang,
Weidong Wei,
Mingqing Wu,
Lu Yang,
Xinhua Xie,
Ning Lv

Published: February 28, 2013
https://doi.org/10.1371/journal.pone.0057092

About the Authors

Yanan Kong

Contributed equally to this work with: Yanan Kong, Junye Wang

Affiliations Department of Breast Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, People’s Republic of China, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, People’s Republic of China

Junye Wang

Contributed equally to this work with: Yanan Kong, Junye Wang

Affiliations State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, People’s Republic of China, Department of Chest Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, People’s Republic of China

Wanli Liu

Affiliations State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, People’s Republic of China, Department of Medical Examination, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, People’s Republic of China

Qiaolun Chen

Juan Yang

Weidong Wei

Mingqing Wu

Lu Yang

Xinhua Xie

Ning Lv

Jiaoli Guo

Laisheng Li

Jie Gao

Xiaoming Xie

* E-mail: daishq@sysucc.org.cn (SD); xiexm@sysucc.org.cn (XX)

Shuqin Dai

* E-mail: daishq@sysucc.org.cn (SD); xiexm@sysucc.org.cn (XX)

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SD Xiaoming Xie WL YK. Performed the experiments: SD YK QC JY. Analyzed the data: YK WW MW LY. Contributed reagents/materials/analysis tools: SD Xiaoming Xie WL YK. Wrote the paper: YK JW Xinhua Xie NL J. Guo LL J. Gao.

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