About the Authors
- Koichi Oishi
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Affiliation Department of Advanced Medicine in Biotechnology and Robotics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
- Yoshitaka Miyamoto
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Affiliation Department of Advanced Medicine in Biotechnology and Robotics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
- Hiroaki Saito
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Affiliation Nagoya Research Laboratory, MEITO Sangyo Co., Ltd., Nagoya, Aichi, Japan
- Katsutoshi Murase
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Affiliation Nagoya Research Laboratory, MEITO Sangyo Co., Ltd., Nagoya, Aichi, Japan
- Kenji Ono
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Affiliation Department of Brain Functions, Division of Stress Adaptation and Protection, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Aichi, Japan
- Makoto Sawada
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Affiliation Department of Brain Functions, Division of Stress Adaptation and Protection, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Aichi, Japan
- Masami Watanabe
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Affiliation Center for Gene and Cell Therapy, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan
- Yasufumi Noguchi
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Affiliation Department of Socio-environmental Design, Hiroshima International University, Kure, Hiroshima, Japan
- Toshiyoshi Fujiwara
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Affiliation Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan
- Shuji Hayashi
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Affiliation Department of Advanced Medicine in Biotechnology and Robotics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
- Hirofumi Noguchi
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* E-mail: noguch-h@cc.okayama-u.ac.jp
Affiliations Department of Advanced Medicine in Biotechnology and Robotics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan, Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan
Competing Interests
The authors have read the journal's policy and have the following conflicts: Murase Katsutoshi has stock options and paid employment at Meito Sangyo, Inc. Hiroaki Saito has ownership of stocks and paid employment at Meito Sangyo, Inc. The following authors have no competing interests: Koichi Oishi, Yoshitaka Miyamoto, Kenji Ono, Makoto Sawada, Masami Watanabe, Yasufumi Noguchi, Toshiyoshi Fujiwara, Shuji Hayashi, Hirofumi Noguchi. MEITO Sangyo Co., Ltd. provided the nanoparticles used in this study (Trimethylamino dextran-coated, magnetic iron oxide nanoparticles (TMADM-03)). This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: HN. Performed the experiments: K. Oishi YM HS KM HN. Analyzed the data: YN HN. Contributed reagents/materials/analysis tools: K. Ono MS MW TF SH. Wrote the paper: K. Oishi HN.