About the Authors

Tao Zhang

Affiliation Division of Neonatology, Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

Junchen Liu

Affiliation Center for Cancer and Stem Cell Biology, Institute of Biosciences and Technology, Texas A & M Health Science Center, Houston, Texas, United States of America

Jue Zhang

Affiliation Morgridge Institute for Research, Madison, Wisconsin, United States of America

Eldhose B. Thekkethottiyil

Affiliation Division of Neonatology, Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

Timothy L. Macatee

Affiliation Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Fraz A. Ismat

Affiliation Division of Cardiology, Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

Fen Wang

Affiliation Center for Cancer and Stem Cell Biology, Institute of Biosciences and Technology, Texas A & M Health Science Center, Houston, Texas, United States of America

Jason Z. Stoller

stoller@email.chop.edu

Affiliation Division of Neonatology, Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

Competing Interests

FAI is currently employed by Bristol-Myers Squibb. The contributions of FAI related to this manuscript occurred while employed at the Children’s Hospital of Philadelphia and prior to employment at Bristol-Myers Squibb. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials. The other authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: FAI JZS. Performed the experiments: TZ JL JZ EBT TLM JZS. Analyzed the data: TZ JL JZ FAI FW JZS. Contributed reagents/materials/analysis tools: TZ EBT TLM FAI JZS. Wrote the paper: FAI JZS.