High Prevalence of Mucosa-Associated E. coli Producing Cyclomodulin and Genotoxin in Colon Cancer

Emmanuel Buc; Damien Dubois; Pierre Sauvanet; Jennifer Raisch; Julien Delmas; Arlette Darfeuille-Michaud; Denis Pezet; Richard Bonnet

doi:10.1371/journal.pone.0056964

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Peer-reviewed

Research Article

High Prevalence of Mucosa-Associated E. coli Producing Cyclomodulin and Genotoxin in Colon Cancer

Emmanuel Buc ,

Contributed equally to this work with: Emmanuel Buc, Damien Dubois, Arlette Darfeuille-Michaud, Denis Pezet, Richard Bonnet

Affiliations UMR 1071 Inserm/Université d'Auvergne, Clermont Université, Clermont-Ferrand, France, USC 2018, INRA, Clermont-Ferrand, France, Service de Chirurgie digestive, CHU Clermont-Ferrand, Clermont-Ferrand, France
⨯
Damien Dubois ,

Contributed equally to this work with: Emmanuel Buc, Damien Dubois, Arlette Darfeuille-Michaud, Denis Pezet, Richard Bonnet

Affiliations UMR 1071 Inserm/Université d'Auvergne, Clermont Université, Clermont-Ferrand, France, USC 2018, INRA, Clermont-Ferrand, France, Service de Bactériologie, CHU Clermont-Ferrand, Clermont-Ferrand, France
⨯
Pierre Sauvanet,

Affiliations UMR 1071 Inserm/Université d'Auvergne, Clermont Université, Clermont-Ferrand, France, USC 2018, INRA, Clermont-Ferrand, France, Service de Chirurgie digestive, CHU Clermont-Ferrand, Clermont-Ferrand, France
⨯
Jennifer Raisch,

Affiliations UMR 1071 Inserm/Université d'Auvergne, Clermont Université, Clermont-Ferrand, France, USC 2018, INRA, Clermont-Ferrand, France
⨯
Julien Delmas,

Affiliations UMR 1071 Inserm/Université d'Auvergne, Clermont Université, Clermont-Ferrand, France, USC 2018, INRA, Clermont-Ferrand, France, Service de Bactériologie, CHU Clermont-Ferrand, Clermont-Ferrand, France
⨯
Arlette Darfeuille-Michaud ,

Contributed equally to this work with: Emmanuel Buc, Damien Dubois, Arlette Darfeuille-Michaud, Denis Pezet, Richard Bonnet

Affiliations UMR 1071 Inserm/Université d'Auvergne, Clermont Université, Clermont-Ferrand, France, USC 2018, INRA, Clermont-Ferrand, France, Service de Bactériologie, CHU Clermont-Ferrand, Clermont-Ferrand, France
⨯
Denis Pezet ,

Contributed equally to this work with: Emmanuel Buc, Damien Dubois, Arlette Darfeuille-Michaud, Denis Pezet, Richard Bonnet

Affiliations UMR 1071 Inserm/Université d'Auvergne, Clermont Université, Clermont-Ferrand, France, USC 2018, INRA, Clermont-Ferrand, France, Service de Chirurgie digestive, CHU Clermont-Ferrand, Clermont-Ferrand, France
⨯
Richard Bonnet

Contributed equally to this work with: Emmanuel Buc, Damien Dubois, Arlette Darfeuille-Michaud, Denis Pezet, Richard Bonnet

* E-mail: rbonnet@chu-clermontferrand.fr

Affiliations UMR 1071 Inserm/Université d'Auvergne, Clermont Université, Clermont-Ferrand, France, USC 2018, INRA, Clermont-Ferrand, France, Service de Bactériologie, CHU Clermont-Ferrand, Clermont-Ferrand, France
⨯

High Prevalence of Mucosa-Associated E. coli Producing Cyclomodulin and Genotoxin in Colon Cancer

Emmanuel Buc,
Damien Dubois,
Pierre Sauvanet,
Jennifer Raisch,
Julien Delmas,
Arlette Darfeuille-Michaud,
Denis Pezet,
Richard Bonnet

Published: February 14, 2013
https://doi.org/10.1371/journal.pone.0056964

About the Authors

Emmanuel Buc

Contributed equally to this work with: Emmanuel Buc, Damien Dubois, Arlette Darfeuille-Michaud, Denis Pezet, Richard Bonnet

Affiliations UMR 1071 Inserm/Université d'Auvergne, Clermont Université, Clermont-Ferrand, France, USC 2018, INRA, Clermont-Ferrand, France, Service de Chirurgie digestive, CHU Clermont-Ferrand, Clermont-Ferrand, France

Damien Dubois

Contributed equally to this work with: Emmanuel Buc, Damien Dubois, Arlette Darfeuille-Michaud, Denis Pezet, Richard Bonnet

Affiliations UMR 1071 Inserm/Université d'Auvergne, Clermont Université, Clermont-Ferrand, France, USC 2018, INRA, Clermont-Ferrand, France, Service de Bactériologie, CHU Clermont-Ferrand, Clermont-Ferrand, France

Pierre Sauvanet

Jennifer Raisch

Affiliations UMR 1071 Inserm/Université d'Auvergne, Clermont Université, Clermont-Ferrand, France, USC 2018, INRA, Clermont-Ferrand, France

Julien Delmas

Arlette Darfeuille-Michaud

Contributed equally to this work with: Emmanuel Buc, Damien Dubois, Arlette Darfeuille-Michaud, Denis Pezet, Richard Bonnet

Denis Pezet

Contributed equally to this work with: Emmanuel Buc, Damien Dubois, Arlette Darfeuille-Michaud, Denis Pezet, Richard Bonnet

Richard Bonnet

Contributed equally to this work with: Emmanuel Buc, Damien Dubois, Arlette Darfeuille-Michaud, Denis Pezet, Richard Bonnet

* E-mail: rbonnet@chu-clermontferrand.fr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RB DP ADM EB DD. Performed the experiments: DD EB PS JR JD. Analyzed the data: DD EB PS JR DP ADM RB. Contributed reagents/materials/analysis tools: DP RB ADM. Wrote the paper: DD EB ADM RB.

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Colon
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HeLa cells
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DNA damage
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