About the Authors

Florian Rieder

Contributed equally to this work with: Florian Rieder, Britta Siegmund

Affiliations Division of Clinical Pharmacology and Section of Gastroenterology, University of Munich, Munich, Germany, Department of Internal Medicine I, University of Regensburg, Regensburg, Germany

Britta Siegmund

Contributed equally to this work with: Florian Rieder, Britta Siegmund

Affiliations Division of Clinical Pharmacology and Section of Gastroenterology, University of Munich, Munich, Germany, Medical Department I, Charité Universitätsmedizin, Campus Benjamin Franklin, Berlin, Germany

Daniela S. Bundschuh

Affiliation Takeda Pharmaceuticals International GmbH, Zurich, Switzerland

Hans-Anton Lehr

Affiliation Institut Universitaire de Pathologie, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland

Stefan Endres

Affiliation Division of Clinical Pharmacology and Section of Gastroenterology, University of Munich, Munich, Germany

Andreas Eigler

andreas.eigler@med.uni-muenchen.de

Affiliation Division of Clinical Pharmacology and Section of Gastroenterology, University of Munich, Munich, Germany

Competing Interests

This study was partly supported by Takeda Pharmaceuticals International GmbH (formerly Nycomed GmbH), the employer of Daniela S. Bundschuh. Roflumilast and pumafentrine are products of Nycomed and were synthesized by the Department of Chemistry at the Nycomed GmbH, Konstanz, Germany, a member of the Takeda Group. There are no further patents, products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: FR BS DSB SE AE. Performed the experiments: FR BS HAL SE AE. Analyzed the data: FR BS. Contributed reagents/materials/analysis tools: FR BS HAL SE AE. Wrote the paper: FR BS DSB HAL SE AE.