TRIF Is Required for TLR4 Mediated Adjuvant Effects on T Cell Clonal Expansion

Siva K. Gandhapudi; Paula M. Chilton; Thomas C. Mitchell

doi:10.1371/journal.pone.0056855

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Open Access

Peer-reviewed

Research Article

TRIF Is Required for TLR4 Mediated Adjuvant Effects on T Cell Clonal Expansion

Siva K. Gandhapudi,

Affiliation Institute for Cellular Therapeutics, University of Louisville School of Medicine, Louisville, Kentucky, United States of America
⨯
Paula M. Chilton,

Affiliation Institute for Cellular Therapeutics, University of Louisville School of Medicine, Louisville, Kentucky, United States of America
⨯
Thomas C. Mitchell

* E-mail: tom.mitchell@louisville.edu

Affiliations Institute for Cellular Therapeutics, University of Louisville School of Medicine, Louisville, Kentucky, United States of America, Department of Microbiology and Immunology, University of Louisville School of Medicine, Louisville, Kentucky, United States of America
⨯

TRIF Is Required for TLR4 Mediated Adjuvant Effects on T Cell Clonal Expansion

Siva K. Gandhapudi,
Paula M. Chilton,
Thomas C. Mitchell

Published: February 15, 2013
https://doi.org/10.1371/journal.pone.0056855

About the Authors

Siva K. Gandhapudi

Affiliation Institute for Cellular Therapeutics, University of Louisville School of Medicine, Louisville, Kentucky, United States of America

Paula M. Chilton

Affiliation Institute for Cellular Therapeutics, University of Louisville School of Medicine, Louisville, Kentucky, United States of America

Thomas C. Mitchell

* E-mail: tom.mitchell@louisville.edu

Affiliations Institute for Cellular Therapeutics, University of Louisville School of Medicine, Louisville, Kentucky, United States of America, Department of Microbiology and Immunology, University of Louisville School of Medicine, Louisville, Kentucky, United States of America

Competing Interests

The authors have declared that no competing interests exists.

Author Contributions

Conceived and designed the experiments: SKG PMC TCM. Performed the experiments: SKG PMC. Analyzed the data: SKG. Contributed reagents/materials/analysis tools: SKG PMC. Wrote the paper: SKG TCM.

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T cells
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Immunologic adjuvants
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Cytotoxic T cells
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Lipids
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Immune receptor signaling
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Interferons
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Spleen
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Immune response
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