About the Authors

Irina Bancos

Contributed equally to this work with: Irina Bancos, John Paul Bida

Affiliation Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America

John Paul Bida

Contributed equally to this work with: Irina Bancos, John Paul Bida

Affiliations Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America, Mayo Graduate School, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America

Defeng Tian

Affiliation Institute for Therapeutics Discovery and Development, College of Pharmacy, University of Minnesota–Twin Cities, Minneapolis, Minnesota, United States of America

Mary Bundrick

Affiliation Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America

Kristen John

Affiliation Institute for Therapeutics Discovery and Development, College of Pharmacy, University of Minnesota–Twin Cities, Minneapolis, Minnesota, United States of America

Molly Nelson Holte

Affiliation Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America

Yeng F. Her

Affiliations Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America, Mayo Graduate School, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America

Debra Evans

Affiliations Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America, Mayo Graduate School, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America

Dyana T. Saenz

Affiliation Department of Molecular Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America

Eric M. Poeschla

Affiliation Department of Molecular Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America

Derek Hook

Affiliation Institute for Therapeutics Discovery and Development, College of Pharmacy, University of Minnesota–Twin Cities, Minneapolis, Minnesota, United States of America

Gunda Georg

Affiliation Institute for Therapeutics Discovery and Development, College of Pharmacy, University of Minnesota–Twin Cities, Minneapolis, Minnesota, United States of America

L. James Maher III

maher@mayo.edu

Affiliation Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: IB JPB DH GG LJM. Performed the experiments: IB JPB DT MB KJ MNH YH DE DS. Analyzed the data: IB JPB DT MB KJ MNH YH DH LJM. Contributed reagents/materials/analysis tools: IB JPB DT MB KJ MNH YH DE DS EP DH GG LJM. Wrote the paper: IB JPB LJM.