About the Authors

David S. Shames

shames.david@gene.com (DSS); Amler.Lukas@gene.com (LCA)

Affiliation Oncology Biomarker Development, Genentech Inc., South San Francisco, California, United States of America

Juliet Carbon

Affiliation Oncology Biomarker Development, Genentech Inc., South San Francisco, California, United States of America

Kim Walter

Affiliation Oncology Biomarker Development, Genentech Inc., South San Francisco, California, United States of America

Adrian M. Jubb

Affiliation Research Pathology, Genentech Inc., South San Francisco, California, United States of America

Cleopatra Kozlowski

Affiliation Safety Assessment Pathology, Genentech Inc., South San Francisco, California, United States of America

Tom Januario

Affiliation Oncology Biomarker Development, Genentech Inc., South San Francisco, California, United States of America

Do An

Affiliation Oncology Biomarker Development, Genentech Inc., South San Francisco, California, United States of America

Ling Fu

Affiliation Oncology Biomarker Development, Genentech Inc., South San Francisco, California, United States of America

Yuanyuan Xiao

Affiliation Biostatistics, Genentech Inc., South San Francisco, California, United States of America

Rajiv Raja

Affiliation Oncology Biomarker Development, Genentech Inc., South San Francisco, California, United States of America

Brittany Jiang

Affiliation Oncology Biomarker Development, Genentech Inc., South San Francisco, California, United States of America

Ashi Malekafzali

Affiliation Oncology Biomarker Development, Genentech Inc., South San Francisco, California, United States of America

Howard Stern

Affiliation Research Pathology, Genentech Inc., South San Francisco, California, United States of America

Jeff Settleman

Affiliation Molecular Diagnostics and Cancer Cell Biology, Genentech Inc., South San Francisco, California, United States of America

Timothy R. Wilson

Affiliation Oncology Biomarker Development, Genentech Inc., South San Francisco, California, United States of America

Garret M. Hampton

Affiliation Oncology Biomarker Development, Genentech Inc., South San Francisco, California, United States of America

Robert L. Yauch

Affiliation Oncology Biomarker Development, Genentech Inc., South San Francisco, California, United States of America

Andrea Pirzkall

Affiliation Early Clinical Development, Genentech Inc., South San Francisco, California, United States of America

Lukas C. Amler

shames.david@gene.com (DSS); Amler.Lukas@gene.com (LCA)

Affiliation Oncology Biomarker Development, Genentech Inc., South San Francisco, California, United States of America

Competing Interests

This study was funded fully by Genentech but there is no competing interest that can bias this work. This affiliation, however, does not alter the authors’ adherence to all PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: DSS LCA. Performed the experiments: JC KM AMJ TJ AD LF BJ HS. Analyzed the data: DSS CK YX JS TRW GMH RLY AP. Contributed reagents/materials/analysis tools: RR AM. Wrote the paper: DSS KW GMH LCA.