Critical Role of H2O2 Generated by NOX4 during Cellular Response under Glucose Deprivation

Satoshi Owada; Yuko Shimoda; Katsuya Tsuchihara; Hiroyasu Esumi

doi:10.1371/journal.pone.0056628

Loading metrics

Open Access

Peer-reviewed

Research Article

Critical Role of H₂O₂ Generated by NOX4 during Cellular Response under Glucose Deprivation

Satoshi Owada,

Affiliations Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Japan, Cancer Physiology Project, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Japan
⨯
Yuko Shimoda,

Affiliations Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Japan, Cancer Physiology Project, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Japan
⨯
Katsuya Tsuchihara,

Affiliations Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Japan, Cancer Physiology Project, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Japan
⨯
Hiroyasu Esumi

* E-mail: hesumi@ncc.go.jp

Affiliations Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Japan, Cancer Physiology Project, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Japan
⨯

Critical Role of H₂O₂ Generated by NOX4 during Cellular Response under Glucose Deprivation

Satoshi Owada,
Yuko Shimoda,
Katsuya Tsuchihara,
Hiroyasu Esumi

Published: March 21, 2013
https://doi.org/10.1371/journal.pone.0056628

About the Authors

Satoshi Owada

Affiliations Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Japan, Cancer Physiology Project, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Japan

Yuko Shimoda

Katsuya Tsuchihara

Hiroyasu Esumi

* E-mail: hesumi@ncc.go.jp

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SO HE KT. Performed the experiments: SO YS. Analyzed the data: SO YS. Wrote the paper: SO HE KT.

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Glucose
Is the Subject Area "Glucose" applicable to this article?

Thanks for your feedback.
Glucose metabolism
Is the Subject Area "Glucose metabolism" applicable to this article?

Thanks for your feedback.
Immunoblotting
Is the Subject Area "Immunoblotting" applicable to this article?

Thanks for your feedback.
Glucose signaling
Is the Subject Area "Glucose signaling" applicable to this article?

Thanks for your feedback.
Small interfering RNA
Is the Subject Area "Small interfering RNA" applicable to this article?

Thanks for your feedback.
Galactose
Is the Subject Area "Galactose" applicable to this article?

Thanks for your feedback.
Fructoses
Is the Subject Area "Fructoses" applicable to this article?

Thanks for your feedback.
Fibroblasts
Is the Subject Area "Fibroblasts" applicable to this article?

Thanks for your feedback.