Diaphanous homolog 3 (Diap3) Overexpression Causes Progressive Hearing Loss and Inner Hair Cell Defects in a Transgenic Mouse Model of Human Deafness

Cynthia J. Schoen; Margit Burmeister; Marci M. Lesperance

doi:10.1371/journal.pone.0056520

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Peer-reviewed

Research Article

Diaphanous homolog 3 (Diap3) Overexpression Causes Progressive Hearing Loss and Inner Hair Cell Defects in a Transgenic Mouse Model of Human Deafness

Cynthia J. Schoen,

Affiliations Neuroscience Program, University of Michigan Health System, Ann Arbor, Michigan, United States of America, Molecular and Behavioral Neuroscience Institute, University of Michigan Health System, Ann Arbor, Michigan, United States of America
⨯
Margit Burmeister,

Affiliations Molecular and Behavioral Neuroscience Institute, University of Michigan Health System, Ann Arbor, Michigan, United States of America, Department of Human Genetics, University of Michigan Health System, Ann Arbor, Michigan, United States of America, Department of Psychiatry, University of Michigan Health System, Ann Arbor, Michigan, United States of America
⨯
Marci M. Lesperance

* E-mail:lesperan@umich.edu

Affiliation Division of Pediatric Otolaryngology, Department of Otolaryngology-Head and Neck Surgery, University of Michigan Health System, Ann Arbor, Michigan, United States of America
⨯

Diaphanous homolog 3 (Diap3) Overexpression Causes Progressive Hearing Loss and Inner Hair Cell Defects in a Transgenic Mouse Model of Human Deafness

Cynthia J. Schoen,
Margit Burmeister,
Marci M. Lesperance

Published: February 18, 2013
https://doi.org/10.1371/journal.pone.0056520

About the Authors

Cynthia J. Schoen

Affiliations Neuroscience Program, University of Michigan Health System, Ann Arbor, Michigan, United States of America, Molecular and Behavioral Neuroscience Institute, University of Michigan Health System, Ann Arbor, Michigan, United States of America

Margit Burmeister

Affiliations Molecular and Behavioral Neuroscience Institute, University of Michigan Health System, Ann Arbor, Michigan, United States of America, Department of Human Genetics, University of Michigan Health System, Ann Arbor, Michigan, United States of America, Department of Psychiatry, University of Michigan Health System, Ann Arbor, Michigan, United States of America

Marci M. Lesperance

* E-mail:lesperan@umich.edu

Affiliation Division of Pediatric Otolaryngology, Department of Otolaryngology-Head and Neck Surgery, University of Michigan Health System, Ann Arbor, Michigan, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CJS MB MML. Performed the experiments: CJS. Analyzed the data: CJS MB MML. Wrote the paper: CJS MB MML.

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Deafness
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Mouse models
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Genetically modified animals
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Cochlea
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Hyperexpression techniques
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Synapses
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Organ of Corti
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Mammalian genomics
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