About the Authors

Alessio Giubellino

giubella@mail.nih.gov (AG); karel@mail.nih.gov (KP)

Affiliation Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health & Human Development, National Institutes of Health, Bethesda, Maryland, United States of America

Carole Sourbier

Affiliation Urologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

Min-Jung Lee

Affiliation Medical Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

Brad Scroggins

Affiliation Urologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

Petra Bullova

Affiliation Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health & Human Development, National Institutes of Health, Bethesda, Maryland, United States of America

Michael Landau

Affiliation Medical Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

Weiwen Ying

Affiliation Synta Pharmaceuticals, Lexington, Massachusetts, United States of America

Len Neckers

Affiliation Urologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

Jane B. Trepel

Contributed equally to this work with: Jane B. Trepel, Karel Pacak

Affiliation Medical Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

Karel Pacak

Contributed equally to this work with: Jane B. Trepel, Karel Pacak

giubella@mail.nih.gov (AG); karel@mail.nih.gov (KP)

Affiliation Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health & Human Development, National Institutes of Health, Bethesda, Maryland, United States of America

Competing Interests

WY is a current employee of Synta Pharmaceuticals. All other authors declare no competing financial interests. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: AG LN JBT KP. Performed the experiments: AG CS MJL BS PB ML. Analyzed the data: AG CS MJL BS PB ML JBT KP. Contributed reagents/materials/analysis tools: WY LN JBT KP. Wrote the paper: AG CS MJL BS PB ML WY LN JBT KP.