About the Authors

Jinpu Yu

Affiliations TMUCIH-JnJ joint laboratory, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China, Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

Xiubao Ren

Affiliation Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

Yongzi Chen

Affiliation Laboratory of Cancer Cell Biology, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

Pengpeng Liu

Affiliations TMUCIH-JnJ joint laboratory, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China, Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

Xiyin Wei

Affiliation Laboratory of Cancer Cell Biology, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

Hui Li

Affiliation Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

Guoguang Ying

Affiliation Laboratory of Cancer Cell Biology, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

Kexin Chen

Affiliation Department of Epidemiology, Tianjin Medical University Cancer Institute & Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

Hans Winkler

Affiliation TMUCIH-JnJ joint laboratory, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

Xishan Hao

hxs_yjp@yahoo.com

Affiliation TMUCIH-JnJ joint laboratory, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

Competing Interests

The authors have the following interests. Tineke Casneuf and Karin Verstraeten are employed by Janssen Research and Development and Hans Winkler by GNS Healthcare. There are no patents, products in development or marketed products to declare. This does not alter the authors‚ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: XH. Performed the experiments: JY PL XW HW. Analyzed the data: JY YC. Contributed reagents/materials/analysis tools: XR HL GY KC. Wrote the paper: JY XH.