About the Authors

Alex Gutteridge

alex.gutteridge@pfizer.com (AG); rownrk@yahoo.co.uk (RKR)

Affiliation Pfizer Regenerative Medicine, Cambridge, United Kingdom

J. Michael Rukstalis

Affiliations Pfizer Regenerative Medicine, Cambridge, Massachusetts, United States of America, Pfizer Cardiovascular and Metabolic Diseases, Cambridge, Massachusetts, United States of America

Daniel Ziemek

Affiliation Pfizer Computational Sciences Center of Emphasis, Cambridge, Massachusetts, United States of America

Mark Tié

Affiliation Pfizer Regenerative Medicine, Cambridge, Massachusetts, United States of America

Lin Ji

Affiliations Pfizer Regenerative Medicine, Cambridge, Massachusetts, United States of America, Pfizer Cardiovascular and Metabolic Diseases, Cambridge, Massachusetts, United States of America

Rebeca Ramos-Zayas

Affiliation Pfizer Regenerative Medicine, Cambridge, Massachusetts, United States of America

Nancy A. Nardone

Affiliation Pfizer Cardiovascular and Metabolic Diseases, Cambridge, Massachusetts, United States of America

Lisa D. Norquay

Affiliation Pfizer Cardiovascular and Metabolic Diseases, Cambridge, Massachusetts, United States of America

Martin B. Brenner

Affiliation Pfizer Cardiovascular and Metabolic Diseases, Cambridge, Massachusetts, United States of America

Kim Tang

Affiliation Pfizer Regenerative Medicine, Cambridge, Massachusetts, United States of America

John D. McNeish

Affiliation Pfizer Regenerative Medicine, Cambridge, Massachusetts, United States of America

Rebecca K. Rowntree

alex.gutteridge@pfizer.com (AG); rownrk@yahoo.co.uk (RKR)

Affiliation Pfizer Regenerative Medicine, Cambridge, Massachusetts, United States of America

Competing Interests

The authors have the following conflicts: authors Alex Gutteridge, J. Michael Rukstalis, Daniel Ziemek, Mark Tié, Lin Ji, Rebeca Ramos-Zayas, Nancy A. Nardone, Lisa D. Norquay, Martin B. Brenner, Kim Tang, John D. McNeish and Rebecca K. Rowntree are affiliated to Pfizer Inc the funder of this study. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: RKR AG DZ JMR KT JDM. Performed the experiments: AG JMR DZ MT LJ RR-Z NAN LDN MBB RKR. Analyzed the data: AG JMR DZ KT RKR. Wrote the paper: AG JMR DZ RKR.