About the Authors

Hai-xia Ji

Contributed equally to this work with: Hai-xia Ji, Yu-lian Zou, Jing-jing Duan

Affiliation State Key Laboratory of Natural Medicines, Academic Institute of Pharmaceutical Science, China Pharmaceutical University, Nanjing, Jiangsu, People’s Republic of China

Yu-lian Zou

Contributed equally to this work with: Hai-xia Ji, Yu-lian Zou, Jing-jing Duan

Affiliation State Key Laboratory of Natural Medicines, Academic Institute of Pharmaceutical Science, China Pharmaceutical University, Nanjing, Jiangsu, People’s Republic of China

Jing-jing Duan

Contributed equally to this work with: Hai-xia Ji, Yu-lian Zou, Jing-jing Duan

Affiliation State Key Laboratory of Natural Medicines, Academic Institute of Pharmaceutical Science, China Pharmaceutical University, Nanjing, Jiangsu, People’s Republic of China

Zhi-rong Jia

Affiliation State Key Laboratory of Natural Medicines, Academic Institute of Pharmaceutical Science, China Pharmaceutical University, Nanjing, Jiangsu, People’s Republic of China

Xian-jing Li

Affiliation State Key Laboratory of Natural Medicines, Academic Institute of Pharmaceutical Science, China Pharmaceutical University, Nanjing, Jiangsu, People’s Republic of China

Zhuo Wang

Affiliation State Key Laboratory of Natural Medicines, Academic Institute of Pharmaceutical Science, China Pharmaceutical University, Nanjing, Jiangsu, People’s Republic of China

Li Li

Affiliation Department of Pharmacology, Department of Physiology, Guilin Medical University, Guilin, Guangxi, People’s Republic of China

Yong-wen Li

Affiliation Department of Pharmacology, Department of Physiology, Guilin Medical University, Guilin, Guangxi, People’s Republic of China

Gen-yan Liu

Affiliation Department of Laboratory Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China

Ming-Qing Tong

Affiliation Department of Laboratory Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China

Xiao-yi Li

Affiliation Hefei Zhaoke Pharmaceutical, Hefei, People’s Republic of China

Guo-hui Zhang

Affiliation Hefei Zhaoke Pharmaceutical, Hefei, People’s Republic of China

Xiang-rong Dai

Affiliation Hefei Zhaoke Pharmaceutical, Hefei, People’s Republic of China

Ling He

Affiliation State Key Laboratory of Natural Medicines, Academic Institute of Pharmaceutical Science, China Pharmaceutical University, Nanjing, Jiangsu, People’s Republic of China

Zhi-yu Li

valianty@hotmail.com (YY); caocong@suda.edu.cn (CC); zhiyuli@263.net (ZL)

Affiliation State Key Laboratory of Natural Medicines, Academic Institute of Pharmaceutical Science, China Pharmaceutical University, Nanjing, Jiangsu, People’s Republic of China

Cong Cao

valianty@hotmail.com (YY); caocong@suda.edu.cn (CC); zhiyuli@263.net (ZL)

Affiliation Neuroscience Institute, Soochow University, Soochow, Jiangsu, People’s Republic of China

Yong Yang

valianty@hotmail.com (YY); caocong@suda.edu.cn (CC); zhiyuli@263.net (ZL)

Affiliation State Key Laboratory of Natural Medicines, Academic Institute of Pharmaceutical Science, China Pharmaceutical University, Nanjing, Jiangsu, People’s Republic of China

Competing Interests

XL and GZ are employed by Hefei Zhaoke Pharmaceutical. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: YY ZL CC. Performed the experiments: HJ YZ GL MT ZJ Xian-jing Li JD. Analyzed the data: YY MT GZ XD ZW LL YL Xian-jing Li LH. Contributed reagents/materials/analysis tools: YY Xiao-yi Li CC. Wrote the paper: HJ YZ CC.