About the Authors

Muhammad Sajid Hamid Akash

Affiliations Institute of Pharmacology, Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University Hangzhou, China, College of Pharmacy, Government College University Faisalabad, Pakistan

Kanwal Rehman

Affiliation Institute of Pharmacology, Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University Hangzhou, China

Hongying Sun

Affiliation Institute of Pharmacology, Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University Hangzhou, China

Shuqing Chen

chenshuqing@zju.edu.cn

Affiliation Institute of Pharmacology, Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University Hangzhou, China

Competing Interests

The authors have the following interests: IL-1Ra was generously provided by Hisun Pharmaceuticals. There are no patents, products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: MSHA SC. Performed the experiments: MSHA KR. Analyzed the data: MSHA KR. Contributed reagents/materials/analysis tools: MSHA KR HS. Wrote the paper: MSHA KR.