About the Authors

Maria Tikhonenko

Affiliation Department of Physiology, Michigan State University, East Lansing, Michigan, United States of America

Todd A. Lydic

Affiliation Department of Physiology, Michigan State University, East Lansing, Michigan, United States of America

Madalina Opreanu

Affiliations Department of Physiology, Michigan State University, East Lansing, Michigan, United States of America, Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan, United States of America

Sergio Li Calzi

Affiliation Department of Pharmacology and Therapeutics University of Florida, Gainesville, Florida, United States of America

Svetlana Bozack

Affiliations Department of Physiology, Michigan State University, East Lansing, Michigan, United States of America, Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan, United States of America

Kelly M. McSorley

Affiliation Department of Physiology, Michigan State University, East Lansing, Michigan, United States of America

Andrew L. Sochacki

Affiliation Department of Physiology, Michigan State University, East Lansing, Michigan, United States of America

Matthew S. Faber

Affiliation Department of Physiology, Michigan State University, East Lansing, Michigan, United States of America

Sugata Hazra

Affiliation Department of Pharmacology and Therapeutics University of Florida, Gainesville, Florida, United States of America

Shane Duclos

Affiliation Biomedical Research Models, Inc., Worcester, Massachusetts, United States of America

Dennis Guberski

Affiliation Biomedical Research Models, Inc., Worcester, Massachusetts, United States of America

Gavin E. Reid

Affiliation Department of Chemistry and Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan, United States of America

Maria B. Grant

Affiliation Department of Pharmacology and Therapeutics University of Florida, Gainesville, Florida, United States of America

Julia V. Busik

busik@msu.edu

Affiliation Department of Physiology, Michigan State University, East Lansing, Michigan, United States of America

Competing Interests

Shane Duclos and Dennis Guberski are employed by Biomedical Research Models, Inc. This does not alter the authors‚ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: MT TAL MO DG GER MBG JVB. Performed the experiments: MT TAL MO SL SB KMM ALS MSF SH SD GER MBG JVB. Analyzed the data: MT TAL GER MBG JVB. Contributed reagents/materials/analysis tools: DG SD GER MBG. Wrote the paper: MT MBG JVB.