Determining Antibody-Binding Site of Streptococcal Pyrogenic Exotoxin B to Protect Mice from Group A Streptococcus Infection

Nina Tsao; Miao-Hui Cheng; Hsiu-Chen Yang; Yu-Chieh Wang; Yi-Ling Liu; Chih-Feng Kuo

doi:10.1371/journal.pone.0055028

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Open Access

Peer-reviewed

Research Article

Determining Antibody-Binding Site of Streptococcal Pyrogenic Exotoxin B to Protect Mice from Group A Streptococcus Infection

Nina Tsao,

Affiliation Department of Biological Science and Technology, I-Shou University, Kaohsiung City, Taiwan
⨯
Miao-Hui Cheng,

Affiliation Department of Biological Science and Technology, I-Shou University, Kaohsiung City, Taiwan
⨯
Hsiu-Chen Yang,

Affiliation Department of Biological Science and Technology, I-Shou University, Kaohsiung City, Taiwan
⨯
Yu-Chieh Wang,

Affiliation Department of Biological Science and Technology, I-Shou University, Kaohsiung City, Taiwan
⨯
Yi-Ling Liu,

Affiliation Department of Nursing, I-Shou University, Kaohsiung City, Taiwan
⨯
Chih-Feng Kuo

* E-mail: kuo@isu.edu.tw

Affiliation Department of Nursing, I-Shou University, Kaohsiung City, Taiwan
⨯

Determining Antibody-Binding Site of Streptococcal Pyrogenic Exotoxin B to Protect Mice from Group A Streptococcus Infection

Nina Tsao,
Miao-Hui Cheng,
Hsiu-Chen Yang,
Yu-Chieh Wang,
Yi-Ling Liu,
Chih-Feng Kuo

Published: January 31, 2013
https://doi.org/10.1371/journal.pone.0055028

About the Authors

Nina Tsao

Affiliation Department of Biological Science and Technology, I-Shou University, Kaohsiung City, Taiwan

Miao-Hui Cheng

Affiliation Department of Biological Science and Technology, I-Shou University, Kaohsiung City, Taiwan

Hsiu-Chen Yang

Affiliation Department of Biological Science and Technology, I-Shou University, Kaohsiung City, Taiwan

Yu-Chieh Wang

Affiliation Department of Biological Science and Technology, I-Shou University, Kaohsiung City, Taiwan

Yi-Ling Liu

Affiliation Department of Nursing, I-Shou University, Kaohsiung City, Taiwan

Chih-Feng Kuo

* E-mail: kuo@isu.edu.tw

Affiliation Department of Nursing, I-Shou University, Kaohsiung City, Taiwan

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: NT CFK. Performed the experiments: MHC HCY YCW YLL. Analyzed the data: NT CFK. Contributed reagents/materials/analysis tools: MHC HCY YCW YLL. Wrote the paper: NT CFK.

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Antibodies
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Enzyme-linked immunoassays
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Group A streptococcal infection
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Complement activation
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Mouse models
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Antibody isotypes
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Binding analysis
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Complement system
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