About the Authors

María C. de Andrés

Affiliations Bone and Joint Research Group, University of Southampton, Southampton, United Kingdom, Centre for Human Development, Stem Cells and Regeneration Human Development and Health, Institute of Developmental Sciences, University of Southampton, Southampton, United Kingdom, Instituto de Investigación Sanitaria-Hospital Clínico Universitario de Santiago, Santiago de Compostela, Spain

Emmajayne Kingham

Affiliations Bone and Joint Research Group, University of Southampton, Southampton, United Kingdom, Centre for Human Development, Stem Cells and Regeneration Human Development and Health, Institute of Developmental Sciences, University of Southampton, Southampton, United Kingdom

Kei Imagawa

Affiliations Bone and Joint Research Group, University of Southampton, Southampton, United Kingdom, Centre for Human Development, Stem Cells and Regeneration Human Development and Health, Institute of Developmental Sciences, University of Southampton, Southampton, United Kingdom, Tohoku University School of Medicine, Sendai, Japan

Antonio Gonzalez

Affiliation Instituto de Investigación Sanitaria-Hospital Clínico Universitario de Santiago, Santiago de Compostela, Spain

Helmtrud I. Roach

† Deceased.

Affiliations Bone and Joint Research Group, University of Southampton, Southampton, United Kingdom, Centre for Human Development, Stem Cells and Regeneration Human Development and Health, Institute of Developmental Sciences, University of Southampton, Southampton, United Kingdom

David I. Wilson

Affiliation Centre for Human Development, Stem Cells and Regeneration Human Development and Health, Institute of Developmental Sciences, University of Southampton, Southampton, United Kingdom

Richard O. C. Oreffo

roco@soton.ac.uk

Affiliations Bone and Joint Research Group, University of Southampton, Southampton, United Kingdom, Centre for Human Development, Stem Cells and Regeneration Human Development and Health, Institute of Developmental Sciences, University of Southampton, Southampton, United Kingdom, Stem Cell Unit, Department of Anatomy, College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia

Competing Interests

The authors have declared that no competing interest exist.

Author Contributions

Conceived and designed the experiments: RO HIR MCA EK. Performed the experiments: MCA EK KI. Analyzed the data: MCA EK KI AG DIW RO. Contributed reagents/materials/analysis tools: HIR RO. Wrote the paper: MCA EK AG DIW RO.