About the Authors

Anna M. Lilja

anna.lilja@ki.se (AL); greign@grc.nia.nih.gov (NHG)

Affiliations Alzheimer Neurobiology Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden, Drug Design and Development Section, Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

Yu Luo

Affiliation Department of Neurological Surgery, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America

Qian-sheng Yu

Affiliation Drug Design and Development Section, Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

Jennie Röjdner

Affiliations Alzheimer Neurobiology Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden, Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden

Yazhou Li

Affiliation Drug Design and Development Section, Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

Ann M. Marini

Affiliation Department of Neurology and Neuroscience Program, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America

Amelia Marutle

Affiliation Alzheimer Neurobiology Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden

Agneta Nordberg

Affiliations Alzheimer Neurobiology Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden, Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden

Nigel H. Greig

anna.lilja@ki.se (AL); greign@grc.nia.nih.gov (NHG)

Affiliation Drug Design and Development Section, Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

Competing Interests

This study was partly funded by a Karolinska Institutet agreement with Johnson & Johnson. There are no patents, products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: AML YL YHL AMM AM AN NHG. Performed the experiments: AML YL QSY AMM. Analyzed the data: AML YL JR AMM. Contributed reagents/materials/analysis tools: AML YL QSY YHL AMM AM AN NHG. Wrote the paper: AML JR AMM AM AN NHG.