About the Authors

Kenta Saito

Contributed equally to this work with: Kenta Saito, Keisuke Horiuchi

Affiliation Department of Orthopedic Surgery, School of Medicine, Keio University, Tokyo, Japan

Keisuke Horiuchi

Contributed equally to this work with: Kenta Saito, Keisuke Horiuchi

horiuchi@z3.keio.jp

Affiliations Department of Orthopedic Surgery, School of Medicine, Keio University, Tokyo, Japan, Department of Anti-Aging Orthopedic Research, School of Medicine, Keio University, Tokyo, Japan

Tokuhiro Kimura

Affiliation Department of Pathology, School of Medicine, Keio University, Tokyo, Japan

Sakiko Mizuno

Affiliation Department of Orthopedic Surgery, School of Medicine, Keio University, Tokyo, Japan

Masaki Yoda

Affiliation Department of Anti-Aging Orthopedic Research, School of Medicine, Keio University, Tokyo, Japan

Hideo Morioka

Affiliation Department of Orthopedic Surgery, School of Medicine, Keio University, Tokyo, Japan

Haruhiko Akiyama

Affiliation Department of Orthopedics, Kyoto University, Kyoto, Japan

David Threadgill

Affiliation Department of Genetics, North Carolina State University, Raleigh, North Carolina, United States of America

Yasunori Okada

Affiliation Department of Pathology, School of Medicine, Keio University, Tokyo, Japan

Yoshiaki Toyama

Affiliation Department of Orthopedic Surgery, School of Medicine, Keio University, Tokyo, Japan

Kazuki Sato

Affiliation Department of Orthopedic Surgery, School of Medicine, Keio University, Tokyo, Japan

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KH. Performed the experiments: K. Saito KH TK SM MY. Analyzed the data: KH TK HM YO YT K. Saito. Contributed reagents/materials/analysis tools: HA DT. Wrote the paper: KH.