About the Authors

Costanza Bogani

Contributed equally to this work with: Costanza Bogani, Niccolò Bartalucci

Affiliation Department of Medical and Surgical Care, Section of Hematology, University of Florence, Florence, Italy

Niccolò Bartalucci

Contributed equally to this work with: Costanza Bogani, Niccolò Bartalucci

Affiliation Department of Medical and Surgical Care, Section of Hematology, University of Florence, Florence, Italy

Serena Martinelli

Affiliation Department of Medical and Surgical Care, Section of Hematology, University of Florence, Florence, Italy

Lorenzo Tozzi

Affiliation Department of Medical and Surgical Care, Section of Hematology, University of Florence, Florence, Italy

Paola Guglielmelli

Affiliation Department of Medical and Surgical Care, Section of Hematology, University of Florence, Florence, Italy

Alberto Bosi

Affiliation Department of Medical and Surgical Care, Section of Hematology, University of Florence, Florence, Italy

Alessandro M. Vannucchi

amvannucchi@unifi.it

Affiliation Department of Medical and Surgical Care, Section of Hematology, University of Florence, Florence, Italy

Competing Interests

A.M. Vannucchi, participated in advisory board meeting (Novartis, Italfarmaco). The JAK1/JAK2 kinase ATP-competitive inhibitors AZD1480 [44] and INC424 (ruxolitinib) were provided by D. Huszar (AstraZeneca, Waltham, MA, USA) and T. Radimeski (Novartis, Basel, CH), respectively. There are no further patents, products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: CB NB PG AMV. Performed the experiments: CB NB SM LT PG. Analyzed the data: CB NB LT PG AB AMV. Wrote the paper: CB NB LT PG AMV.