About the Authors

Zhen Xia

Affiliations Computational Biology Center, IBM Thomas J. Watson Research Center, Yorktown Heights, New York, New York, United States of America, Department of Biomedical Engineering, The University of Texas at Austin, Austin, Texas, United States of America

Tien Huynh

Affiliation Computational Biology Center, IBM Thomas J. Watson Research Center, Yorktown Heights, New York, New York, United States of America

Pengyu Ren

Affiliation Department of Biomedical Engineering, The University of Texas at Austin, Austin, Texas, United States of America

Ruhong Zhou

ruhongz@us.ibm.com

Affiliations Computational Biology Center, IBM Thomas J. Watson Research Center, Yorktown Heights, New York, New York, United States of America, Department of Chemistry, Columbia University, New York, New York, United States of America

Competing Interests

The authors have the following interests: This work was supported by the IBM Blue Gene Science program. Co-authors Zhen Xia, Tien Huynh and Ruhong Zhou are affiliated with IBM Research. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: RZ. Performed the experiments: TH ZX RZ. Analyzed the data: RZ ZX. Wrote the paper: RZ ZX TH PR.