Effector Protein Translocation by the Coxiella burnetii Dot/Icm Type IV Secretion System Requires Endocytic Maturation of the Pathogen-Occupied Vacuole

Hayley J. Newton; Justin A. McDonough; Craig R. Roy

doi:10.1371/journal.pone.0054566

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Open Access

Peer-reviewed

Research Article

Effector Protein Translocation by the Coxiella burnetii Dot/Icm Type IV Secretion System Requires Endocytic Maturation of the Pathogen-Occupied Vacuole

Hayley J. Newton ,

* E-mail: hayley.newton@yale.edu

Affiliation Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, United States of America
⨯
Justin A. McDonough,

Affiliation Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, United States of America
⨯
Craig R. Roy

Affiliation Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, United States of America
⨯

Effector Protein Translocation by the Coxiella burnetii Dot/Icm Type IV Secretion System Requires Endocytic Maturation of the Pathogen-Occupied Vacuole

Hayley J. Newton,
Justin A. McDonough,
Craig R. Roy

Published: January 17, 2013
https://doi.org/10.1371/journal.pone.0054566

About the Authors

Hayley J. Newton

* E-mail: hayley.newton@yale.edu

Affiliation Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, United States of America

Justin A. McDonough

Affiliation Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, United States of America

Craig R. Roy

Affiliation Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HJN CRR. Performed the experiments: HJN JAM. Analyzed the data: HJN. Contributed reagents/materials/analysis tools: HJN JAM. Wrote the paper: HJN CRR.

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Coxiella burnetii
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Host cells
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Cell fusion
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Legionella pneumophila
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HeLa cells
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Intracellular pathogens
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Vacuoles
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Cytosol
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