About the Authors

Ling-Zhi Wang

Affiliations Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore, Department of Pharmacology, National University of Singapore, Singapore, Singapore

Jacqueline Ramírez

Affiliation Department of Medicine, The University of Chicago, Chicago, Illinois, United States of America

Winnie Yeo

Affiliation Department of Clinical Oncology, Chinese University of Hong Kong, Hong Kong, China

Mei-Yi Michelle Chan

Affiliation Department of Pharmacy, National University of Singapore, Singapore, Singapore

Win-Lwin Thuya

Affiliation Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

Jie-Ying Amelia Lau

Affiliation Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

Seow-Ching Wan

Affiliation Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

Andrea Li-Ann Wong

Affiliation Department of Hematology & Oncology, National University Health System, Singapore, Singapore

Ying-Kiat Zee

Affiliation Department of Hematology & Oncology, National University Health System, Singapore, Singapore

Robert Lim

Affiliation Department of Hematology & Oncology, National University Health System, Singapore, Singapore

Soo-Chin Lee

Affiliations Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore, Department of Hematology & Oncology, National University Health System, Singapore, Singapore

Paul C. Ho

Affiliation Department of Pharmacy, National University of Singapore, Singapore, Singapore

How-Sung Lee

Affiliation Department of Pharmacology, National University of Singapore, Singapore, Singapore

Anthony Chan

Affiliation Department of Clinical Oncology, Chinese University of Hong Kong, Hong Kong, China

Sherry Ansher

Affiliation Cancer Therapy Evaluation Program, Bethesda, Maryland, United States of America

Mark J. Ratain

Affiliations Department of Medicine, The University of Chicago, Chicago, Illinois, United States of America, Committee on Clinical Pharmacology and Pharmacogenomics, The University of Chicago, Chicago, Illinois, United States of America, Comprehensive Cancer Center, The University of Chicago, Chicago, Illinois, United States of America

Boon-Cher Goh

phcgbc@nus.edu.sg

Affiliations Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore, Department of Pharmacology, National University of Singapore, Singapore, Singapore, Department of Hematology & Oncology, National University Health System, Singapore, Singapore

Competing Interests

The authors have declared that no competing interests exist. Please note that belinostat is a Topotarget product. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: BCG LZW WY AC SA. Performed the experiments: LZW JR MYMC WLT JYAL SCW ALAW YKZ RL. Analyzed the data: BCG MJR LZW JR WY SCL PCH HSL AC ALAW YKZ RL. Contributed reagents/materials/analysis tools: WY MJR HSL PCH AC SA. Wrote the paper: BCG LZW MJR JR PCH HSL.