Identification of a Small Molecule That Modifies MglA/SspA Interaction and Impairs Intramacrophage Survival of Francisella tularensis

Algevis P. Wrench; Christopher L. Gardner; Claudio F. Gonzalez; Graciela L. Lorca

doi:10.1371/journal.pone.0054498

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Open Access

Peer-reviewed

Research Article

Identification of a Small Molecule That Modifies MglA/SspA Interaction and Impairs Intramacrophage Survival of Francisella tularensis

Algevis P. Wrench,

Affiliation Department of Microbiology and Cell Science, Genetics Institute, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, Florida, United States of America
⨯
Christopher L. Gardner,

Affiliation Department of Microbiology and Cell Science, Genetics Institute, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, Florida, United States of America
⨯
Claudio F. Gonzalez,

Affiliation Department of Microbiology and Cell Science, Genetics Institute, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, Florida, United States of America
⨯
Graciela L. Lorca

* E-mail: glorca@ufl.edu

Affiliation Department of Microbiology and Cell Science, Genetics Institute, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, Florida, United States of America
⨯

Identification of a Small Molecule That Modifies MglA/SspA Interaction and Impairs Intramacrophage Survival of Francisella tularensis

Algevis P. Wrench,
Christopher L. Gardner,
Claudio F. Gonzalez,
Graciela L. Lorca

Published: January 23, 2013
https://doi.org/10.1371/journal.pone.0054498

About the Authors

Algevis P. Wrench

Affiliation Department of Microbiology and Cell Science, Genetics Institute, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, Florida, United States of America

Christopher L. Gardner

Affiliation Department of Microbiology and Cell Science, Genetics Institute, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, Florida, United States of America

Claudio F. Gonzalez

Affiliation Department of Microbiology and Cell Science, Genetics Institute, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, Florida, United States of America

Graciela L. Lorca

* E-mail: glorca@ufl.edu

Affiliation Department of Microbiology and Cell Science, Genetics Institute, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, Florida, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AW CG CFG GL. Performed the experiments: AW CG. Analyzed the data: AW CG CFG GL. Wrote the paper: AW CG CFG GL.

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Francisella tularensis
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Gene expression
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Small molecules
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Macrophages
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DNA transcription
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Yersinia pestis
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Plasmid construction
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Transcription factors
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