About the Authors

Vesa-Petteri Kouri

Contributed equally to this work with: Vesa-Petteri Kouri, Juri Olkkonen

Affiliations Department of Medicine, Institute of Clinical Medicine, University of Helsinki, Helsinki, Finland, Department of Anatomy, Institute of Biomedicine, University of Helsinki, Helsinki, Finland

Juri Olkkonen

Contributed equally to this work with: Vesa-Petteri Kouri, Juri Olkkonen

Affiliation Department of Medicine, Institute of Clinical Medicine, University of Helsinki, Helsinki, Finland

Emilia Kaivosoja

Affiliation Department of Medicine, Institute of Clinical Medicine, University of Helsinki, Helsinki, Finland

Mari Ainola

Affiliations Department of Medicine, Institute of Clinical Medicine, University of Helsinki, Helsinki, Finland, Department of Medicine/invärtes medicin, Helsinki University Central Hospital, Helsinki, Finland

Juuso Juhila

Affiliation Research Program of Molecular Neurology and Department of Medical Genetics, Haartman Institute, University of Helsinki, Helsinki, Finland

Iiris Hovatta

Affiliations Research Program of Molecular Neurology and Department of Medical Genetics, Haartman Institute, University of Helsinki, Helsinki, Finland, Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland

Yrjö T. Konttinen

Affiliations Department of Medicine, Institute of Clinical Medicine, University of Helsinki, Helsinki, Finland, Department of Medicine/invärtes medicin, Helsinki University Central Hospital, Helsinki, Finland, ORTON Orthopedic Hospital of the ORTON Foundation, Helsinki, Finland, COXA Hospital for Joint Replacement, Tampere, Finland

Jami Mandelin

jami.mandelin@helsinki.fi

Affiliations Department of Medicine, Institute of Clinical Medicine, University of Helsinki, Helsinki, Finland, Department of Medicine/invärtes medicin, Helsinki University Central Hospital, Helsinki, Finland, ORTON Orthopedic Hospital of the ORTON Foundation, Helsinki, Finland

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: VPK JO JJ IH JM. Performed the experiments: VPK JO JJ JM. Analyzed the data: VPK JO MA EK YTK JM. Contributed reagents/materials/analysis tools: EK MA YTK JM. Wrote the paper: IH YTK JM.