About the Authors

Fernando Lopez-Rios

flopezrios@hospitaldemadrid.com

Affiliation Laboratorio de Dianas Terapéuticas, Hospital Universitario Sanchinarro, Madrid, Spain

Barbara Angulo

Affiliation Laboratorio de Dianas Terapéuticas, Hospital Universitario Sanchinarro, Madrid, Spain

Belen Gomez

Affiliation The Royal Marsden NHS Trust and The Institute of Cancer Research, Sutton, London, United Kingdom

Debbie Mair

Affiliation The Royal Marsden NHS Trust and The Institute of Cancer Research, Sutton, London, United Kingdom

Rebeca Martinez

Affiliation Laboratorio de Dianas Terapéuticas, Hospital Universitario Sanchinarro, Madrid, Spain

Esther Conde

Affiliation Laboratorio de Dianas Terapéuticas, Hospital Universitario Sanchinarro, Madrid, Spain

Felice Shieh

Affiliation Roche Molecular Systems, Pleasanton, California, United States of America

Jeffrey Vaks

Affiliation Roche Molecular Systems, Pleasanton, California, United States of America

Rachel Langland

Affiliation Roche Molecular Systems, Pleasanton, California, United States of America

H. Jeffrey Lawrence

Affiliation Roche Molecular Systems, Pleasanton, California, United States of America

David Gonzalez de Castro

Affiliation The Royal Marsden NHS Trust and The Institute of Cancer Research, Sutton, London, United Kingdom

Competing Interests

FS, JV, and RL are employees of Roche Molecular Systems, the funder of this study. HJL is a former employee of Roche Molecular Systems. DGdC declares the receipt of honoraria from Roche Molecular Systems (Pleasanton, CA) and Roche Products Ltd (UK). FLR declares the receipt of honoraria from Roche Molecular Systems (Pleasanton, CA) and Roche Diagnostics (Spain). Miller Medical was contracted by Roche Molecular Systems and contributed in the drafting of this manuscript. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: FLR DGdC HJL FS. Performed the experiments: BA RM BG DM JV EC RL. Analyzed the data: FLR DGdC HJL FS BA RM BG DM EC JV RL. Wrote the paper: FLR DGdC HJL FS BA RM BG DM EC JV RL.