NOS Inhibition Enhances Myogenic Tone by Increasing Rho-Kinase Mediated Ca2+ Sensitivity in the Male but Not the Female Gerbil Spiral Modiolar Artery

Katrin Reimann; Gayathri Krishnamoorthy; Philine Wangemann

doi:10.1371/journal.pone.0053655

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Peer-reviewed

Research Article

NOS Inhibition Enhances Myogenic Tone by Increasing Rho-Kinase Mediated Ca²⁺ Sensitivity in the Male but Not the Female Gerbil Spiral Modiolar Artery

Katrin Reimann ,

Contributed equally to this work with: Katrin Reimann, Gayathri Krishnamoorthy

Affiliations Department of Anatomy and Physiology, Kansas State University, Manhattan, Kansas, United States of America, Universitätsklinik für Hals-, Nasen- und Ohrenheilkunde, Eberhard-Karls Universität, Tübingen, Germany
⨯
Gayathri Krishnamoorthy ,

Contributed equally to this work with: Katrin Reimann, Gayathri Krishnamoorthy

Affiliation Department of Anatomy and Physiology, Kansas State University, Manhattan, Kansas, United States of America
⨯
Philine Wangemann

* E-mail: wange@vet.ksu.edu

Affiliation Department of Anatomy and Physiology, Kansas State University, Manhattan, Kansas, United States of America
⨯

NOS Inhibition Enhances Myogenic Tone by Increasing Rho-Kinase Mediated Ca²⁺ Sensitivity in the Male but Not the Female Gerbil Spiral Modiolar Artery

Katrin Reimann,
Gayathri Krishnamoorthy,
Philine Wangemann

Published: January 3, 2013
https://doi.org/10.1371/journal.pone.0053655

About the Authors

Katrin Reimann

Contributed equally to this work with: Katrin Reimann, Gayathri Krishnamoorthy

Affiliations Department of Anatomy and Physiology, Kansas State University, Manhattan, Kansas, United States of America, Universitätsklinik für Hals-, Nasen- und Ohrenheilkunde, Eberhard-Karls Universität, Tübingen, Germany

Gayathri Krishnamoorthy

Contributed equally to this work with: Katrin Reimann, Gayathri Krishnamoorthy

Affiliation Department of Anatomy and Physiology, Kansas State University, Manhattan, Kansas, United States of America

Philine Wangemann

* E-mail: wange@vet.ksu.edu

Affiliation Department of Anatomy and Physiology, Kansas State University, Manhattan, Kansas, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KR GK PW. Performed the experiments: KR GK. Analyzed the data: KR GK PW. Contributed reagents/materials/analysis tools: PW. Wrote the paper: KR GK PW. Designed equipment: PW. Wrote software: PW.

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Nitric oxide
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Smooth muscle cells
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Blood flow
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Myosins
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Arteries
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