A Global Transcriptome Analysis Reveals Molecular Hallmarks of Neural Stem Cell Death, Survival, and Differentiation in Response to Partial FGF-2 and EGF Deprivation

Vanesa Nieto-Estévez; Jaime Pignatelli; Marcos J. Araúzo-Bravo; Anahí Hurtado-Chong; Carlos Vicario-Abejón

doi:10.1371/journal.pone.0053594

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Peer-reviewed

Research Article

A Global Transcriptome Analysis Reveals Molecular Hallmarks of Neural Stem Cell Death, Survival, and Differentiation in Response to Partial FGF-2 and EGF Deprivation

Vanesa Nieto-Estévez,

Affiliations Instituto Cajal, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
⨯
Jaime Pignatelli,

Affiliations Instituto Cajal, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
⨯
Marcos J. Araúzo-Bravo,

Affiliation Laboratory of Computational Biology and Bioinformatics, Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, Muenster, Germany
⨯
Anahí Hurtado-Chong,

Affiliation Instituto Cajal, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain
⨯
Carlos Vicario-Abejón

* E-mail: cvicario@cajal.csic.es

Affiliations Instituto Cajal, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
⨯

A Global Transcriptome Analysis Reveals Molecular Hallmarks of Neural Stem Cell Death, Survival, and Differentiation in Response to Partial FGF-2 and EGF Deprivation

Vanesa Nieto-Estévez,
Jaime Pignatelli,
Marcos J. Araúzo-Bravo,
Anahí Hurtado-Chong,
Carlos Vicario-Abejón

Published: January 7, 2013
https://doi.org/10.1371/journal.pone.0053594

About the Authors

Vanesa Nieto-Estévez

Affiliations Instituto Cajal, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain

Jaime Pignatelli

Marcos J. Araúzo-Bravo

Affiliation Laboratory of Computational Biology and Bioinformatics, Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, Muenster, Germany

Anahí Hurtado-Chong

Affiliation Instituto Cajal, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain

Carlos Vicario-Abejón

* E-mail: cvicario@cajal.csic.es

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: VN-E JP CV-A. Performed the experiments: VN-E AH-C. Analyzed the data: VN-E JP MJA-B CV-A. Contributed reagents/materials/analysis tools: MJA-B CV-A. Wrote the paper: VN-E CV-A.

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Neurospheres
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Neuronal differentiation
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Gene expression
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Cell differentiation
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Cell cycle and cell division
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Cell death
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Growth factors
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Apoptosis
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