Inhibition of PI3K/Akt Pathway Impairs G2/M Transition of Cell Cycle in Late Developing Progenitors of the Avian Embryo Retina

Isis Moraes Ornelas; Thayane Martins Silva; Lucianne Fragel-Madeira; Ana Lucia Marques Ventura

doi:10.1371/journal.pone.0053517

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Open Access

Peer-reviewed

Research Article

Inhibition of PI3K/Akt Pathway Impairs G2/M Transition of Cell Cycle in Late Developing Progenitors of the Avian Embryo Retina

Isis Moraes Ornelas,

Affiliation Department of Neurobiology, Neuroscience Program, Institute of Biology, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil
⨯
Thayane Martins Silva,

Affiliation Department of Neurobiology, Neuroscience Program, Institute of Biology, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil
⨯
Lucianne Fragel-Madeira,

Affiliation Department of Neurobiology, Neuroscience Program, Institute of Biology, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil
⨯
Ana Lucia Marques Ventura

* E-mail: almv@vm.uff.br

Affiliation Department of Neurobiology, Neuroscience Program, Institute of Biology, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil
⨯

Inhibition of PI3K/Akt Pathway Impairs G2/M Transition of Cell Cycle in Late Developing Progenitors of the Avian Embryo Retina

Isis Moraes Ornelas,
Thayane Martins Silva,
Lucianne Fragel-Madeira,
Ana Lucia Marques Ventura

Published: January 2, 2013
https://doi.org/10.1371/journal.pone.0053517

About the Authors

Isis Moraes Ornelas

Affiliation Department of Neurobiology, Neuroscience Program, Institute of Biology, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil

Thayane Martins Silva

Affiliation Department of Neurobiology, Neuroscience Program, Institute of Biology, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil

Lucianne Fragel-Madeira

Affiliation Department of Neurobiology, Neuroscience Program, Institute of Biology, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil

Ana Lucia Marques Ventura

* E-mail: almv@vm.uff.br

Affiliation Department of Neurobiology, Neuroscience Program, Institute of Biology, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: IMO ALMV. Performed the experiments: IMO TMS LFM. Analyzed the data: IMO TMS LFM ALMV. Contributed reagents/materials/analysis tools: ALMV. Wrote the paper: ALMV.

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Retina
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Cyclins
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Mitosis
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Monolayer cultures
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Cell cycle and cell division
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Cell cycle inhibitors
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Phosphorylation
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Synthesis phase
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