Homing of Regulatory T Cells to Human Skin Is Important for the Prevention of Alloimmune-Mediated Pathology in an In Vivo Cellular Therapy Model

Fadi Issa; Joanna Hester; Kate Milward; Kathryn J. Wood

doi:10.1371/journal.pone.0053331

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Open Access

Peer-reviewed

Research Article

Homing of Regulatory T Cells to Human Skin Is Important for the Prevention of Alloimmune-Mediated Pathology in an In Vivo Cellular Therapy Model

Fadi Issa ,

Contributed equally to this work with: Fadi Issa, Joanna Hester

Affiliation Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford
⨯
Joanna Hester ,

Contributed equally to this work with: Fadi Issa, Joanna Hester

Affiliation Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford
⨯
Kate Milward,

Affiliation Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford
⨯
Kathryn J. Wood

* E-mail: kathryn.wood@nds.ox.ac.uk

Affiliation Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford
⨯

Homing of Regulatory T Cells to Human Skin Is Important for the Prevention of Alloimmune-Mediated Pathology in an In Vivo Cellular Therapy Model

Fadi Issa,
Joanna Hester,
Kate Milward,
Kathryn J. Wood

Published: December 31, 2012
https://doi.org/10.1371/journal.pone.0053331

About the Authors

Fadi Issa

Contributed equally to this work with: Fadi Issa, Joanna Hester

Affiliation Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford

Joanna Hester

Contributed equally to this work with: Fadi Issa, Joanna Hester

Affiliation Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford

Kate Milward

Affiliation Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford

Kathryn J. Wood

* E-mail: kathryn.wood@nds.ox.ac.uk

Affiliation Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: FI JH KM KJW. Performed the experiments: FI JH KM. Analyzed the data: FI JH KM. Contributed reagents/materials/analysis tools: FI JH KJW. Wrote the paper: FI JH KM KJW.

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Regulatory T cells
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Skin grafting
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Skin
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Lymph nodes
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Blood
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Flow cytometry
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Dermatologic pathology
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Homing behavior
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