About the Authors

Ryan M. Fryer

ryan.fryer@boehringer-ingelheim.com

Affiliation Department of Cardiometabolic Disease Research, Boehringer-Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut, United States of America

Akalushi Muthukumarana

Affiliation Department of Cardiometabolic Disease Research, Boehringer-Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut, United States of America

Paul C. Harrison

Affiliation Department of Cardiometabolic Disease Research, Boehringer-Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut, United States of America

Suzanne Nodop Mazurek

Affiliation Department of Cardiometabolic Disease Research, Boehringer-Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut, United States of America

Rong Rhonda Chen

Affiliation Department of Cardiometabolic Disease Research, Boehringer-Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut, United States of America

Kyle E. Harrington

Affiliation Department of Drug Discovery Support, Boehringer-Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut, United States of America

Roger M. Dinallo

Affiliation Department of Drug Discovery Support, Boehringer-Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut, United States of America

Joshua C. Horan

Affiliation Department of Medicinal Chemistry, Boehringer-Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut, United States of America

Lori Patnaude

Affiliation Department of Immunology and Inflammation, Boehringer-Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut, United States of America

Louise K. Modis

Affiliation Department of Immunology and Inflammation, Boehringer-Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut, United States of America

Glenn A. Reinhart

Affiliation Department of Cardiometabolic Disease Research, Boehringer-Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut, United States of America

Competing Interests

All authors were employed by Boehringer-Ingelheim Pharmaceuticals, Inc. at the time the research was performed. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials. The authors have declared that no other competing interests exist.

Author Contributions

Conceived and designed the experiments: RMF LKM GAR. Performed the experiments: AM PCH SNM RRC KEH RMD LP JCH. Analyzed the data: RMF AM PCH SNM RRC KEH RMD JCH LP LKM. Contributed reagents/materials/analysis tools: JCH. Wrote the paper: RMF LKM.