About the Authors

Tao Wang

Contributed equally to this work with: Tao Wang, Chao Xu

Affiliation Hefei National Laboratory for Physical Sciences at Microscale, School of Life Science, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China

Chao Xu

Contributed equally to this work with: Tao Wang, Chao Xu

Affiliation Structural Genomics Consortium and Department of Physiology, University of Toronto, Toronto, Ontario, Canada

Yanli Liu

Affiliations Structural Genomics Consortium and Department of Physiology, University of Toronto, Toronto, Ontario, Canada, Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Science, Huazhong Normal University, Wuhan, People's Republic of China

Kai Fan

Affiliation Hefei National Laboratory for Physical Sciences at Microscale, School of Life Science, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China

Zhihong Li

Affiliation Structural Genomics Consortium and Department of Physiology, University of Toronto, Toronto, Ontario, Canada

Xing Sun

Affiliation Structural Genomics Consortium and Department of Physiology, University of Toronto, Toronto, Ontario, Canada

Hui Ouyang

Affiliation Structural Genomics Consortium and Department of Physiology, University of Toronto, Toronto, Ontario, Canada

Xuecheng Zhang

Affiliation School of Life Sciences, Anhui University, Hefei, Anhui, People’s Republic of China

Jiahai Zhang

Affiliation Hefei National Laboratory for Physical Sciences at Microscale, School of Life Science, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China

Yanjun Li

Affiliation Structural Genomics Consortium and Department of Physiology, University of Toronto, Toronto, Ontario, Canada

Farrell MacKenzie

Affiliation Structural Genomics Consortium and Department of Physiology, University of Toronto, Toronto, Ontario, Canada

Jinrong Min

jr.min@utoronto.ca (JM); xmtu@ustc.edu.cn (XT)

Affiliations Structural Genomics Consortium and Department of Physiology, University of Toronto, Toronto, Ontario, Canada, Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Science, Huazhong Normal University, Wuhan, People's Republic of China

Xiaoming Tu

jr.min@utoronto.ca (JM); xmtu@ustc.edu.cn (XT)

Affiliation Hefei National Laboratory for Physical Sciences at Microscale, School of Life Science, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China

Competing Interests

The authors declare that they received funding from commercial sources - GlaxoSmithKline and Merck & Co., Inc. However, this does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: TW CX JM XT. Performed the experiments: TW CX Y. Liu KF ZL XS HO Y. Li FM. Analyzed the data: TW CX Y. Liu KF. Contributed reagents/materials/analysis tools: XZ JZ. Wrote the paper: TW CX JM XT.