About the Authors

Ojore Oka

# These authors contributed equally to this work.

Affiliation Department of Biochemistry, University of Leicester, Henry Wellcome Building, Leicester, United Kingdom

Lorna C. Waters

lw83@le.ac.uk (LW); mdc12@le.ac.uk (MDC)

# These authors contributed equally to this work.

Affiliation Department of Biochemistry, University of Leicester, Henry Wellcome Building, Leicester, United Kingdom

Sarah L. Strong

Affiliation Department of Biochemistry, University of Leicester, Henry Wellcome Building, Leicester, United Kingdom

Nuvjeevan S. Dosanjh

Affiliation Department of Biochemistry, University of Leicester, Henry Wellcome Building, Leicester, United Kingdom

Vaclav Veverka

Affiliation Department of Biochemistry, University of Leicester, Henry Wellcome Building, Leicester, United Kingdom

Frederick W. Muskett

Affiliation Department of Biochemistry, University of Leicester, Henry Wellcome Building, Leicester, United Kingdom

Philip S. Renshaw

Affiliation Department of Biochemistry, University of Leicester, Henry Wellcome Building, Leicester, United Kingdom

Karl-Heinz Klempnauer

Affiliation Institut für Biochemie, Westfälische-Wilhelms-Universität, Münster, Germany

Mark D. Carr

lw83@le.ac.uk (LW); mdc12@le.ac.uk (MDC)

Affiliation Department of Biochemistry, University of Leicester, Henry Wellcome Building, Leicester, United Kingdom

Competing Interests

Limited support for the work reported in the paper was provided by UCB Celltech Ltd through support for the Research Fellow position held by Vaclav Veverka. However, this does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: OO LCW NSD KHK MDC. Performed the experiments: OO LCW SLS NSD VV FWM. Analyzed the data: OO LCW VV FWM PSR KHK MDC. Contributed reagents/materials/analysis tools: FWM PSR KHK. Wrote the paper: OO LCW KHK MDC.