About the Authors

Morito Takano

Affiliations Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan, Department of Physiology, Keio University School of Medicine, Tokyo, Japan

Keigo Hikishima

Affiliations Department of Physiology, Keio University School of Medicine, Tokyo, Japan, Central Institute for Experimental Animals, Kawasaki, Kanagawa, Japan

Kanehiro Fujiyoshi

Affiliation National Hospital Organization Murayama Medical Center, Tokyo, Japan

Shinsuke Shibata

Affiliation Department of Physiology, Keio University School of Medicine, Tokyo, Japan

Akimasa Yasuda

Affiliation Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan

Tsunehiko Konomi

Affiliations Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan, Department of Physiology, Keio University School of Medicine, Tokyo, Japan

Akiko Hayashi

Affiliation Department of Molecular Neurobiology, Tokyo University of Pharmacy and Life Science, Tokyo, Japan

Hiroko Baba

Affiliation Department of Molecular Neurobiology, Tokyo University of Pharmacy and Life Science, Tokyo, Japan

Koichi Honke

Affiliation Department of Biochemistry, Kochi University Medical School, Nankoku, Kochi, Japan

Yoshiaki Toyama

Affiliation Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan

Hideyuki Okano

Affiliation Department of Physiology, Keio University School of Medicine, Tokyo, Japan

Masaya Nakamura

masa@a8.keio.jp

Affiliation Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan

Competing Interests

The authors received funding from a commercial source (General Insurance Association of Japan), but this does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: MT K. Hikishima KF HO MN. Performed the experiments: MT K. Hikishima SS AY. Analyzed the data: MT K. Hikishima KF TK. Contributed reagents/materials/analysis tools: AH HB K. Honke YT HO MN. Wrote the paper: MT K. Hikishima KF HO MN.