About the Authors

Masamichi Hirose

mhirose@iwate-med.ac.jp

Affiliation Department of Molecular and Cellular Pharmacology, Iwate Medical University School of Pharmaceutical Sciences, Shiwa, Iwate, Japan

Yasuchika Takeishi

Affiliation Department of Cardiology and Hematology, Fukushima Medical University, Fukushima, Fukushima, Japan

Tsutomu Nakada

Affiliation Department of Molecular Pharmacology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan

Hisashi Shimojo

Affiliation Department of Pathology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan

Toshihide Kashihara

Affiliation Department of Molecular Pharmacology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan

Ayako Nishio

Affiliation The Research Center for Human and Environmental Science, Shinshu University, Matsumoto, Nagano, Japan

Satoshi Suzuki

Affiliation Department of Cardiology and Hematology, Fukushima Medical University, Fukushima, Fukushima, Japan

Ulrike Mende

Affiliation Cardiovascular Research Center, Division of Cardiology, Rhode Island Hospital & The Alpert Medical School of Brown University, Providence, Rhode Island, United States of America

Kiyoshi Matsumoto

Affiliation The Research Center for Human and Environmental Science, Shinshu University, Matsumoto, Nagano, Japan

Naoko Matsushita

Affiliation Department of Pharmacology, Iwate Medical University School of Medicine, Shiwa, Iwate, Japan

Eiichi Taira

Affiliation Department of Pharmacology, Iwate Medical University School of Medicine, Shiwa, Iwate, Japan

Fumika Sato

Affiliation Department of Molecular and Cellular Pharmacology, Iwate Medical University School of Pharmaceutical Sciences, Shiwa, Iwate, Japan

Mitsuhiko Yamada

Affiliation Department of Molecular Pharmacology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MH YT KM MY. Performed the experiments: MH HS TN TK AN SS NM FS. Analyzed the data: MH HS TN TK SS. Contributed reagents/materials/analysis tools: MH YT UM. Wrote the paper: MH UM MY ET.