Dopamine Transporter Loss in 6-OHDA Parkinson’s Model Is Unmet by Parallel Reduction in Dopamine Uptake

Tanya Chotibut; Deana M. Apple; Rebecca Jefferis; Michael F. Salvatore

doi:10.1371/journal.pone.0052322

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Open Access

Peer-reviewed

Research Article

Dopamine Transporter Loss in 6-OHDA Parkinson’s Model Is Unmet by Parallel Reduction in Dopamine Uptake

Tanya Chotibut ,

Contributed equally to this work with: Tanya Chotibut, Deana M. Apple

Affiliation Department of Pharmacology, Toxicology, and Neuroscience, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America
⨯
Deana M. Apple ,

Contributed equally to this work with: Tanya Chotibut, Deana M. Apple

Affiliation Department of Pharmacology, Toxicology, and Neuroscience, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America
⨯
Rebecca Jefferis,

Affiliation Department of Pharmacology, Toxicology, and Neuroscience, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America
⨯
Michael F. Salvatore

* E-mail: msalva@lsuhsc.edu

Affiliation Department of Pharmacology, Toxicology, and Neuroscience, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America
⨯

Dopamine Transporter Loss in 6-OHDA Parkinson’s Model Is Unmet by Parallel Reduction in Dopamine Uptake

Tanya Chotibut,
Deana M. Apple,
Rebecca Jefferis,
Michael F. Salvatore

Published: December 26, 2012
https://doi.org/10.1371/journal.pone.0052322

About the Authors

Tanya Chotibut

Contributed equally to this work with: Tanya Chotibut, Deana M. Apple

Affiliation Department of Pharmacology, Toxicology, and Neuroscience, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America

Deana M. Apple

Contributed equally to this work with: Tanya Chotibut, Deana M. Apple

Affiliation Department of Pharmacology, Toxicology, and Neuroscience, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America

Rebecca Jefferis

Affiliation Department of Pharmacology, Toxicology, and Neuroscience, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America

Michael F. Salvatore

* E-mail: msalva@lsuhsc.edu

Affiliation Department of Pharmacology, Toxicology, and Neuroscience, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MFS TC DMA. Performed the experiments: TC RJ DMA. Analyzed the data: MFS TC DMA. Contributed reagents/materials/analysis tools: MFS. Wrote the paper: TC DMA MFS.

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Neostriatum
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Levodopa
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Synaptosomes
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Serotonin
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Parkinson disease
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Biological locomotion
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Dopamine transporters
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Dopamine
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