About the Authors

Anna Mondini

Contributed equally to this work with: Anna Mondini, Francesca Sassone

Affiliation Department of Life Sciences, Università degli Studi di Milano, Milano, Italy

Francesca Sassone

Contributed equally to this work with: Anna Mondini, Francesca Sassone

Affiliation Department of Life Sciences, Università degli Studi di Milano, Milano, Italy

Davide Antonio Civello

Affiliation Department of Life Sciences, Università degli Studi di Milano, Milano, Italy

Maria Lisa Garavaglia

Affiliation Department of Life Sciences, Università degli Studi di Milano, Milano, Italy

Claudia Bazzini

Affiliation Department of Life Sciences, Università degli Studi di Milano, Milano, Italy

Simona Rodighiero

Affiliation Fondazione Filarete, Milano, Italy

Valeria Vezzoli

Affiliation Department of Life Sciences, Università degli Studi di Milano, Milano, Italy

Fabio Conti

Affiliation Prassis Research Institute, Sigma Tau, Settimo M.se, Italy

Lucia Torielli

Affiliation Prassis Research Institute, Sigma Tau, Settimo M.se, Italy

Giovanbattista Capasso

Affiliation Department of Internal Medicine, Second University of Napoli, Napoli, Italy

Markus Paulmichl

Affiliation Institut of Pharmacology and Toxicology, Paracelsus Medical University, Salzburg, Austria

Giuliano Meyer

giuliano.meyer@unimi.it

Affiliation Department of Life Sciences, Università degli Studi di Milano, Milano, Italy

Competing Interests

Co-author SR is a Fondazione Filarete employee. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: AM MLG CB SR. Performed the experiments: AM FS MLG CB SR DAC VV. Analyzed the data: AM FS MLG CB SR GM. Contributed reagents/materials/analysis tools: FC LT GC MP SR. Wrote the paper: AM FS MLG CB GM.