About the Authors

Yanxing Chen

Contributed equally to this work with: Yanxing Chen, Zhu Tian

Affiliations Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, United States of America, Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, China

Zhu Tian

Contributed equally to this work with: Yanxing Chen, Zhu Tian

Affiliations Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, United States of America, Department of Neurology, The First Hospital of Jilin University, Changchun, Jilin, China

Zhihou Liang

Affiliation Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, China

Shenggang Sun

Affiliation Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, China

Chun-ling Dai

Affiliation Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, United States of America

Moon H. Lee

Affiliation Department of Developmental Neurobiology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, United States of America

Frank M. LaFerla

Affiliation Department of Neurobiology and Behavior, University of California Irvine, Irvine, California, United States of America

Inge Grundke-Iqbal

Affiliation Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, United States of America

Khalid Iqbal

Affiliation Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, United States of America

Fei Liu

Affiliation Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, United States of America

Cheng-Xin Gong

chengxin.gong@csi.cuny.edu

Affiliation Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, United States of America

Competing Interests

Co-author Cheng-Xin Gong is a PLOS ONE Editorial Board member and is a member of the Scientific Advisory Board of Alectos Therapeutics, Inc., Burnaby, Canada. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: YC ZT CXG. Performed the experiments: YC ZT CLD. Analyzed the data: YC ZT ZL SS CLD IGI KI FL CXG. Contributed reagents/materials/analysis tools: MHL FML IGI KI FL CXG. Wrote the paper: YC ZT CXG.